Novel protein kinase C inhibitors: alpha-terthiophene derivatives

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2695-8. doi: 10.1016/s0960-894x(98)00468-5.
D S Kim  1 ,  C L Ashendel ,  Q Zhou ,  C T Chang ,  E S Lee ,  C J Chang
Affiliations
  • 1. Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907-1333, USA.
PMID: 9873605 DOI: 10.1016/s0960-894x(98)00468-5
Abstract

A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 microM). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.