Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium

  • J Nat Prod. 1999 Jan;62(1):80-5. doi: 10.1021/np980219f.
J M Gerard  1 ,  P Haden ,  M T Kelly ,  R J Andersen
Affiliations
  • 1. Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
PMID: 9917287 DOI: 10.1021/np980219f
Abstract

Loloatins A (1) to D (4), a family of new cyclic decapeptide Antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae.

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