Potent 3-spiropiperidine growth hormone secretagogues

  • Bioorg Med Chem Lett. 1998 Jan 6;8(1):107-12. doi: 10.1016/s0960-894x(97)10199-8.
L Yang  1 ,  G Morriello ,  K Prendergast ,  K Cheng ,  T Jacks ,  W W Chan ,  K D Schleim ,  R G Smith ,  A A Patchett
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
PMID: 9925440 DOI: 10.1016/s0960-894x(97)10199-8
Abstract

Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretagogues with low nanomolar in vitro activity.