2. Cell Cycle/DNA Damage
  3. CDK
  4. QR-6401

QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer.

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QR-6401

QR-6401 화학구조

CAS No. : 2845096-18-4

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제품 설명

QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].

Cellular Effect
Cell Line Type Value Description References
OVCAR-3 IC50
34 nM
Compound: 23; QR-6401
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation incubated for 6 days by CyQUANT reagent assay
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation incubated for 6 days by CyQUANT reagent assay
[PMID: 36923916]
분자량

369.42

화학식

C19H23N5O3
CAS No.
SMILES

O=C(N[C@H](C1)C[C@@H]1OC2)O[C@@H](C3)CC[C@@H]3C4=CC(NC5=NC2=CC=C5)=NN4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QR-64012845096-18-4QR6401QR 6401CDKCyclin dependent kinaseOVCAR3cancertumorInhibitorinhibitorinhibit

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QR-6401
Cat. No.:
HY-153221
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