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(±)12-HEPE

(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM).

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  • CAS No.: 81187-21-5
  • Formula: C20H30O3
  • Molecular Weight:318.45
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • (±)12-HEPE Chemical Structure
    (±)12-HEPE Chemical Structure
CAS No.: 81187-21-5
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  • (±)12-HEPE Chemical Structure
    (±)12-HEPE Chemical Structure
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  • (±)12-HEPE