2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. RC98

RC98 is a monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) and acts as a selective PD-L1 inhibitor. RC98 binds specifically to human and cynomolgus monkey PD-L1. RC98 blocks the interaction between PD-L1 and its receptor PD-1 to reverse T-cell inactivation mediated by PD-1/PD-L1 signaling. RC98 enhances the cytotoxic T-lymphocyte-mediated anti-tumor immune response against PD-L1-expressing tumor cells. RC98 can be used for the research of tumor immunity and solid tumors.

For research use only. We do not sell to patients.

RC98

RC98 Chemical Structure

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Description

RC98 is a monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) and acts as a selective PD-L1 inhibitor. RC98 binds specifically to human and cynomolgus monkey PD-L1. RC98 blocks the interaction between PD-L1 and its receptor PD-1 to reverse T-cell inactivation mediated by PD-1/PD-L1 signaling. RC98 enhances the cytotoxic T-lymphocyte-mediated anti-tumor immune response against PD-L1-expressing tumor cells. RC98 can be used for the research of tumor immunity and solid tumors[1].

Species Reactivity

Human
Parmacokinetics
Species Dose Route Tmax T1/2 Cmax V
Cynomolgus Monkey[1] 15 (first administration) mg/kg i.v. 0.33 h 93.1 h 503 μg/mL 0.05 mL/kg
Cynomolgus Monkey[1] 15 (last administration) mg/kg i.v. 0.33 h 46.20 h 313 μg/mL 0.04 mL/kg
In Vivo

RC98 (15 mg/kg; i.v.; once weekly; 4 weeks) activates the immune system in cynomolgus monkeys, as evidenced by up to 64.5% PD-L1 receptor occupancy on CD3+ T cells, enhanced KLH-induced T-cell-dependent antibody responses, and elevated soluble PD-L1 concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (half female and half male)[1]
Dosage: 15 mg/kg
Administration: i.v.; once weekly; 4 weeks
Result: Reached a mean peak PD-L1 receptor occupancy of 64.5% on CD3+ T cells within 24 h after the first infusion.
Showed reduced receptor occupancy after repeated dosing but maintained levels above background throughout testing.
Elevated anti-KLH IgM levels versus controls at 168 h, 336 h, and 504 h post-first dose.
Increased anti-KLH IgG levels versus controls at multiple time points post-first and last doses.
Induced sustained elevation of soluble PD-L1 with a strong correlation to serum RC98 concentrations.
Gene ID

29126  [NCBI]

Accession
Target

B7-H1/PD-L1/CD274
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RC98 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RC98RC 98RC-98PD-1/PD-L1PD-1/Programmed death-ligand 1B7 family proteinsPD-L1KLHT-cell-dependent antibody responseCD3+ T cellscynomolgus monkeyPD-L1 receptor occupancyhumansolid tumorsInhibitorinhibitorinhibit

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