Ribociclib impurity 1

Cat. No.: HY-78750: Data Sheet
SDS
Handling Instructions
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Ribociclib impurity 1 is an impurity of Ribociclib.

For research use only. We do not sell to patients.

Ribociclib impurity 1 Chemical Structure

CAS No. : 1211443-61-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Purity & Documentation
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Description

Ribociclib impurity 1 is an impurity of Ribociclib.

Molecular Weight

292.77

Formula

C₁₄H₁₇ClN₄O

CAS No.

1211443-61-6

Appearance

Solid

SMILES

O=C(C1=CC=2C=NC(Cl)=NC2N1C3CCCC3)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (341.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4157 mL	17.0783 mL	34.1565 mL
5 mM	0.6831 mL	3.4157 mL	6.8313 mL
10 mM	0.3416 mL	1.7078 mL	3.4157 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (244 KB) SDS (252 KB) Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4157 mL	17.0783 mL	34.1565 mL	85.3913 mL
	5 mM	0.6831 mL	3.4157 mL	6.8313 mL	17.0783 mL
	10 mM	0.3416 mL	1.7078 mL	3.4157 mL	8.5391 mL
	15 mM	0.2277 mL	1.1386 mL	2.2771 mL	5.6928 mL
	20 mM	0.1708 mL	0.8539 mL	1.7078 mL	4.2696 mL
	25 mM	0.1366 mL	0.6831 mL	1.3663 mL	3.4157 mL
	30 mM	0.1139 mL	0.5693 mL	1.1386 mL	2.8464 mL
	40 mM	0.0854 mL	0.4270 mL	0.8539 mL	2.1348 mL
	50 mM	0.0683 mL	0.3416 mL	0.6831 mL	1.7078 mL
	60 mM	0.0569 mL	0.2846 mL	0.5693 mL	1.4232 mL
	80 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0674 mL
	100 mM	0.0342 mL	0.1708 mL	0.3416 mL	0.8539 mL