Rimteravimab
Based on 1 Customer Validation
Rimteravimab (XVR011) is a bivalent VHH-Fc antibody with potent neutralizing activity with high stability, broad coverage and silenced Fc effector functions against the disease caused by SARS-CoV-2.
For research use only. We do not sell to patients.
- Purity: ≥99%
- CAS No.: 2540797-21-3
- Molecular Weight:79.1 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
[G1 VH-h-CH2-CH3] - dimer
Virus
SARS-CoV-2 S protein
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:K18-hACE2 transgenic mouse model[2]
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Dosage:4-20 mg/kg
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Administration:ip, single dose
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Result:Reduced the infectious virus and viral genomic RNA in lungs.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[G1 VH-h-CH2-CH3]-dimer
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ELISA, FACS, Functional assay
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Loaded Rimteravimab on AHC2 biosensor, can bind SARS-CoV-2 S Protein RBD (sf9, His, HY-P73664) with an affinity constant of 8.111E-09 M as determined in BLI assay.
Chemical Information
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CAS No. 2540797-21-3
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Appearance Liquid
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Molecular Weight 79.1 kDa
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Color Colorless to light yellow
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SMILES
[Rimteravimab]
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Synonyms
XVR011
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Bert Schepens, et al. An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models. Sci Transl Med. 2021 Nov 24;13(621):eabi7826. [Content Brief]
[2]. Schepens B, et al., An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models. Sci Transl Med. 2021 Nov 24;13(621):eabi7826. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rimteravimab Related Classifications
HY-P99947 Related Classifications
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