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Art. -Nr.: HY-177105A

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(S)-JNJ-6640

Name: (S)-JNJ-6640
Brand: MedChemExpress
SKU: HY-177105A
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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(S)-JNJ-6640 is an isomer of JNJ-6640 (HY-177105). JNJ-6640 is an inhibitor that targets mycobacterial PurF and exhibits potent anti-tuberculosis activity. JNJ-6640 can be used in tuberculosis research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.94%
CAS. Nr.: 3132220-69-7
Formel: C₁₇H₁₇FN₆O
Molecular Weight:340.35

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(S)-JNJ-6640 Chemical Structure

CAS. Nr.: 3132220-69-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bacterial InfectionNucleotide Metabolism

Bacterial Infection

Nucleotide Metabolism

(S)-JNJ-6640 is an isomer of JNJ-6640 (HY-177105). JNJ-6640 is an inhibitor targeting mycobacterial PurF (the first enzyme in the de novo purine biosynthesis pathway) and exhibits potent anti-tuberculosis activity. JNJ-6640 shows bactericidal activity against Mycobacterium tuberculosis in vitro, with an MIC₉₀ of 8.6 nM. JNJ-6640 interferes with de novo purine biosynthesis and inhibits DNA replication of Mycobacterium tuberculosis in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

(S)-JNJ-6640 is an isomer of JNJ-6640 (HY-177105). JNJ-6640 exhibits anti-tuberculosis efficacy in acutely infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3132220-69-7
Appearance Solid
Molecular Weight 340.35
Formel C₁₇H₁₇FN₆O
Color White to off-white
SMILES

CC1=NNC(OC2=C(F)C=NC(N3C[C@@H](CC3)C4=CC=NC=C4)=N2)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (293.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9382 mL

14.6908 mL

29.3815 mL

5 mM

0.5876 mL

2.9382 mL

5.8763 mL

10 mM

0.2938 mL

1.4691 mL

2.9382 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lamprecht DA, et al. Targeting de novo purine biosynthesis for tuberculosis treatment. Nature. 2025 Aug;644(8075):214-220. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9382 mL	14.6908 mL	29.3815 mL	73.4538 mL
	5 mM	0.5876 mL	2.9382 mL	5.8763 mL	14.6908 mL
	10 mM	0.2938 mL	1.4691 mL	2.9382 mL	7.3454 mL
	15 mM	0.1959 mL	0.9794 mL	1.9588 mL	4.8969 mL
	20 mM	0.1469 mL	0.7345 mL	1.4691 mL	3.6727 mL
	25 mM	0.1175 mL	0.5876 mL	1.1753 mL	2.9382 mL
	30 mM	0.0979 mL	0.4897 mL	0.9794 mL	2.4485 mL
	40 mM	0.0735 mL	0.3673 mL	0.7345 mL	1.8363 mL
	50 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4691 mL
	60 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL
	80 mM	0.0367 mL	0.1836 mL	0.3673 mL	0.9182 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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(S)-JNJ-6640

Biologische Aktivität

Beschreibung

In Vitro

In Vivo

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

In Vivo Dissolution Calculator

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(S)-JNJ-6640 Related Classifications

HY-177105A Related Classifications

Bioz

Keywords

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