(S)-Ketorolac
Based on 1 Customer Validation
(S)-Ketorolac is a nonsteroidal anti-inflammatory agent. (S)-ketorolac exhibits potent COX1 and COX2 enzyme inhibition.
For research use only. We do not sell to patients.
- Purity : 98.93%
- CAS No.: 66635-92-5
- Formula: C15H13NO3
- Molecular Weight:255.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
COX1, COX2[1]
Chemical Information
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CAS No. 66635-92-5
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Appearance Solid
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Molecular Weight 255.27
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Formula C15H13NO3
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@@H]3C(O)=O
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Synonyms
(-)-Ketorolac
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 200 mg/mL (783.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (273 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9174 mL | 19.5871 mL | 39.1742 mL | 97.9355 mL |
| 5 mM | 0.7835 mL | 3.9174 mL | 7.8348 mL | 19.5871 mL | |
| 10 mM | 0.3917 mL | 1.9587 mL | 3.9174 mL | 9.7936 mL | |
| 15 mM | 0.2612 mL | 1.3058 mL | 2.6116 mL | 6.5290 mL | |
| 20 mM | 0.1959 mL | 0.9794 mL | 1.9587 mL | 4.8968 mL | |
| 25 mM | 0.1567 mL | 0.7835 mL | 1.5670 mL | 3.9174 mL | |
| 30 mM | 0.1306 mL | 0.6529 mL | 1.3058 mL | 3.2645 mL | |
| 40 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4484 mL | |
| 50 mM | 0.0783 mL | 0.3917 mL | 0.7835 mL | 1.9587 mL | |
| 60 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL | |
| 80 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL | |
| 100 mM | 0.0392 mL | 0.1959 mL | 0.3917 mL | 0.9794 mL |
(S)-Ketorolac Related Classifications
HY-B0580A Related Classifications
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