eIF4E-IN-1
eIF4E-IN-1 is a potent inhibitor of eIF4E. eIF4E-IN-1 inhibits immunosuppression components such as immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immune suppression in certain diseases, such as cancer and infectious disease (extracted from patent WO2021003194A1, compound Y).
For research use only. We do not sell to patients.
- CAS No.: 2573979-31-2
- Formula: C33H28ClF3N6O4S
- Molecular Weight:697.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
eIF4E[1]
Chemical Information
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CAS No. 2573979-31-2
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Molecular Weight 697.13
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Formula C33H28ClF3N6O4S
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SMILES
N#CC1=C(N2CCN(CC2)C)C(C(F)(F)F)=CC3=C1C(N(CCOC4=CC=C(C=C4C5=C(SC=C6C(O)=O)C6=NC(C)=C5)Cl)C(C)=N3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Hot Topics
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Topics
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Topics Immune Checkpoint: A Critical Target In Tumor Therapy
Immune checkpoints are inhibitory or costimulatory pathways that regulate T-cell activation, peripheral tolerance, and antitumor immune responses, and tumors can exploit these pathways to restrict effector T-cell function and establish immune escape.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)