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Cat. No.: HY-121652

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Mefox

Name: Mefox
Brand: MedChemExpress
SKU: HY-121652
Price: 1180.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

Mefox is a biologically inactive oxidation product of 5-MTHF (HY-113046). Mefox is a stable biomarker of folate metabolism and oxidative stress. Mefox is used as a B vitamin standard for UHPLC-SRM MS quantification.

For research use only. We do not sell to patients.

Purity : 99.89%
CAS No.: 79573-48-1
Formula: C₂₀H₂₃N₇O₇
Molecular Weight:473.44

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Mefox Chemical Structure

CAS No.: 79573-48-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

In Vitro

Nucleotide Metabolism

MeFox accumulates dramatically in Arabidopsis rosette leaves overexpressing ZmGFT-B73, whereas MeFox was undetectable in wild-type leaves^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

ROS/oxidative-stress fluorescent staining

Chemical Information

CAS No. 79573-48-1
Appearance Solid
Molecular Weight 473.44
Formula C₂₀H₂₃N₇O₇
Color Light yellow to yellow
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C)C(C(N3C2)=NC(N)=NC3=O)=O)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ringling C, et al. Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate. Nutrients. 2017 Sep 01;9(9):969.

[2]. Zhang H, et al. Validated B vitamin quantification from lentils by selected reaction monitoring mass spectrometry. Food chemistry. 2021 Oct 15;359:129810.

[3]. Shahid M, et al. Folate monoglutamate in cereal grains: Evaluation of extraction techniques and determination by LC-MS/MS. Journal of Food Composition and Analysis. 2020 Aug 1;91:103510.

[4]. Rudolf Moser, et al. Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid. Patent, WO2018178144A1.

[5]. Liang Q, et al. Creation of folate-biofortified rice by simultaneously enhancing biosynthetic flux and blocking folate oxidation. Molecular Plant. 2024 Oct 7;17(10):1487-9.

[6]. Lian T, et al. An Allele of Glutamate Formiminotransferase Triggers 5-Methyl-Tetrahydrofolate-to-MeFox Conversion and Facilitates Folate Biofortification in Maize. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 Nov;12(42):e15082.

[7]. Heughebaert L, et al. Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies?. The Analyst. 2024 Jan 29;149(3):895-908.

[8]. Fang YW, et al. Glyphosate Exposure, Oxidative Stress, Mitochondrial Dysfunction, and Mortality Risk in US Adults: Insights from the National Health and Nutrition Examination Survey. Toxics. 2025 May 04;13(5):373.

[9]. Munezero E, et al. Identifying the Safe and Adequate Folic Acid Intake Range Using Biomarkers in 2 Mouse Models. The Journal of nutrition. 2025 Dec;155(12):4320-4330.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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