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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
239 Results for "
mouse TNF
" in MedChemExpress (MCE) Product Catalog:
Products (239)
239 Results for "mouse TNF" in MCE Product Catalog:
Cat. No.: HY-P78243
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF17; TNFRSF13A; Prev. BCMA; Tumor Necrosis Factor Receptor Superfamily, Member 17; BCM; B Cell Maturation Antigen; Tumor Necrosis Factor Receptor Superfamily Member 17; B-Cell Maturation Factor; B-Cell Maturation Protein; CD269 Antigen; TNF Receptor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78296
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FAS; Fas (TNF Receptor Superfamily, Member 6); Prev. TNFRSF6; Apoptosis Signaling Receptor FAS; Prev. APT1; Apo-1 Antigen; Prev. FAS1; CD95 Antigen; Tumor Necrosis Factor Receptor Superfamily Member 6; Mutant Tumor Necrosis Receptor Superfamily Member 6;
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78926
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF13C; BLyS Receptor 3; TNF Receptor Superfamily Member 13C; B Cell-Activating Factor Receptor; BAFFR; B-Cell-Activating Factor Receptor; BAFF Receptor; CD268 Antigen; BAFF-R; Prolixin; CD268; BROMIX; Tumor Necrosis Factor Receptor Superfamily, Member
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73837A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF14; Tumor Necrosis Factor Ligand Superfamily Member 14; TNF Superfamily Member 14; Herpesvirus Entry Mediator Ligand; LIGHT; HVEML; HVEM-L; Tumor Necrosis Factor Superfamily Member 14; CD258; Herpes Virus Entry Mediator Ligand; LTg; Tumor Necrosis Fa
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P700221AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF14; Tumor Necrosis Factor Ligand Superfamily Member 14; TNF Superfamily Member 14; Herpesvirus Entry Mediator Ligand; LIGHT; HVEML; HVEM-L; Tumor Necrosis Factor Superfamily Member 14; CD258; Herpes Virus Entry Mediator Ligand; LTg; Tumor Necrosis Fa
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P7425C
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of Nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of Nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P704400
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF14; Tumor Necrosis Factor Ligand Superfamily Member 14; TNF Superfamily Member 14; Herpesvirus Entry Mediator Ligand; LIGHT; HVEML; HVEM-L; Tumor Necrosis Factor Superfamily Member 14; CD258; Herpes Virus Entry Mediator Ligand; LTg; Tumor Necrosis Fa
Species:
Mouse
Source:
HEK293
Cat. No.: HY-178356
Research Areas:
BChE-IN-44 is a potent, brain-penetrant, highly selective BChE inhibitor [equine BChE IC50 = 18.00 pM, human BChE IC50 = 1.50 nM]. BChE-IN-44 shows neuroprotective effects against the Aβ1-42-induced injury model and inhibitory effects on Aβ1-42 self-aggregation. BChE-IN-44 reduces the levels of inflammatory factors (NO, IL-6, and TNF-α) in Lipopolysaccharides (HY-D1056)-induced BV2 cells. BChE-IN-44 can significantly ameliorate Scopolamine (HY-N0296)-induced cognition impairment. BChE-IN-44 exhibits capacity in the regulation of BChE and acetylcholine levels in the mouse hippocampus. BChE-IN-44 can be used for the study of Alzheimer’s disease (AD) .
Cat. No.: HY-181576
CAS No.: 3115784-59-0
Target:
Research Areas:
ROCK2-IN-14 is an orally active, selective ROCK2 inhibitor (IC50=4.8 nM) with 212-fold selectivity over ROCK1 (IC50=1.01 μM). By inhibiting the ROCK2/S100A9 signaling pathway, ROCK2-IN-14 downregulates S100A9 expression, inhibits NM2 phosphorylation and restores cytoskeletal abnormalities. Furthermore, ROCK2-IN-14 reduces inflammatory cytokine levels, alleviates skin inflammation and exerts anti-inflammatory activity. ROCK2-IN-14 also significantly inhibits ear thickening in a mouse model of atopic dermatitis (AD), and decreases the levels of IgE, TNF-α, IL-6 and TSLP. ROCK2-IN-14 can be used for research on atopic dermatitis .
Cat. No.: HY-182707
CAS No.: 2055045-42-4
Target:
Research Areas:
JWX-A0108 is a selective human α7 nAChR positive allosteric modulator with an EC50 of 4.35 μM. JWX-A0108 potentiates α7 nAChR currents only in the presence of acetylcholine, with no direct activating effect or alteration of desensitization. JWX-A0108 enhances hippocampal GABAergic synaptic transmission by increasing spontaneous inhibitory postsynaptic currents. JWX-A0108 reduces the brain expression levels of IL-1β, TNF-α, and IL-6 by blocking the NF-κB signaling pathway, and reduces microglial activation by downregulating Iba1. JWX-A0108 effectively improves cognitive deficits, neuroinflammation, and hippocampal neuronal damage in mouse models of schizophrenia and Alzheimer's disease. JWX-A0108 can be used for research related to schizophrenia and Alzheimer's disease .
Cat. No.: HY-184915
CAS No.: 3065495-08-8
Research Areas:
APH003 is an orally active IRAK4 PROTAC degrader with a DC50 of 0.74 nM in human peripheral blood mononuclear cells (hPBMCs). APH003 recruits IRAK4 to CRBN to form a ternary complex, mediates the ubiquitination and degradation of IRAK4 via the ubiquitin-proteasome pathway, and inhibits the kinase activity of IRAK4. APH003 inhibits LPS- or IL-1β/LPS-induced phosphorylation of ERK, JNK and NF-κB. APH003 inhibits the secretion of TNF-α, IL-6, IL-8 and IL-13 by stimulated hPBMCs. APH003 exhibits anti-inflammatory activity in rat TNBS-induced intestinal inflammation models and mouse IL-33-induced skin inflammation models. APH003 can be used in research related to inflammatory bowel disease and skin inflammation .
Cat. No.: HY-187563
Target:
Research Areas:
RNP-11 is a selective COX-2 inhibitor with an IC50 of 42.85 μg/mL against human COX-2, and also acts as a bactericide and anti-inflammatory agent. RNP-11 inhibits the production of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β, disrupts bacterial cell membranes and induces bacterial cell death. RNP-11 exhibits activity against strains of Staphylococcus and Enterococcus, including Methicillin (HY-121544)-resistant Staphylococcus aureus and Vancomycin (HY-B0671)-resistant Enterococcus faecium. RNP-11 reduces the load of Staphylococcus aureus, exerting dual effects of pathogen clearance and inflammatory response alleviation in a mouse skin infection model,. RNP-11 can be used in research related to infections caused by Staphylococcus, Staphylococcus aureus and Enterococcus faecium .
Cat. No.: HY-B0742S1
Synonyms: 17α-Hydroxyprogesterone hexanoate-d8; 17α-Hydroxyprogesterone caproate-d8
Cat. No.: HY-P991193
Target:
Research Areas:
Cat. No.: HY-P7538
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF13; ZTNF2; TNF Superfamily Member 13; Tumor Necrosis Factor Ligand Superfamily Member 13 Epsilon; APRIL; Tumor Necrosis Factor-Related Death Ligand-1; Tumor Necrosis Factor Ligand Superfamily Member 13; Tumor Necrosis Factor Superfamily Member 13; A
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70363
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTBR; Tumor Necrosis Factor Receptor Type III; Prev. D12S370; TNFR3; TNFRSF3; Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3); TNFCR; TNFR Superfamily, Member 3; TNF-R-III; Lymphotoxin-Beta Receptor; TNFR2-RP; Lymphotoxin B Receptor; TNFR-RP; LT-BE
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P71992
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF14; Herpes Virus Entry Mediator A; TNF Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor Superfamily, Member 14; HVEM; Tumor Necrosis Factor Receptor-Like Gene2; HVEA; Tumor Necrosis Factor Receptor-Like 2; TR2; Herpesvirus Entry Mediat
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73108
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF14; Herpes Virus Entry Mediator A; TNF Receptor Superfamily Member 14; Tumor Necrosis Factor Receptor Superfamily, Member 14; HVEM; Tumor Necrosis Factor Receptor-Like Gene2; HVEA; Tumor Necrosis Factor Receptor-Like 2; TR2; Herpesvirus Entry Mediat
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70821
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript Variant 1, MRNA; TRAIL-R2; P53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P71378
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10B; ZTNFR9; TNF Receptor Superfamily Member 10b; CDNA FLJ76289, Highly Similar To Homo Sapiens Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B), Transcript Variant 1, MRNA; TRAIL-R2; P53-Regulated DNA Damage-Inducible Cell Death R
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
