Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
271 Results for "
trimer
" in MedChemExpress (MCE) Product Catalog:
Products (271)
271 Results for "trimer" in MCE Product Catalog:
Cat. No.: HY-169357B
Research Areas:
Acepromazine-1-piperazinepropanamine dihydrochloride (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. Acepromazine-1-piperazinepropanamine dihydrochloride can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .
Cat. No.: HY-129133
CAS No.: 168037-22-7
Category:
Target:
Cat. No.: HY-P3385
CAS No.: 2254278-53-8
Synonyms: SCB-313
Target:
Research Areas:
Cat. No.: HY-160412
CAS No.: 2248726-53-4
Synonyms: SAR-441566; TNFα activity modulator 3
Target:
Research Areas:
Balinatunfib (SAR-441566) is an orally active inhibitor of TNFR1 signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to TNFR1 (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases .
Cat. No.: HY-N3540
CAS No.: 354553-35-8
Target:
Cat. No.: HY-P704654
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Human coronAvirus HKU1 (isolate N5) (HCoV-HKU1) Spike Protein (S1+S2, His)
Species:
Virus
Source:
HEK293
Cat. No.: HY-111255AR
CAS No.: 1049741-03-8
Target:
Research Areas:
SPD304 dihydrochloride (Standard) is the analytical standard of SPD304 (dihydrochloride) (HY-111255A). This product is intended for research and analytical applications. SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
Cat. No.: HY-111255R
CAS No.: 869998-49-2
Target:
Research Areas:
SPD304 (Standard) is the analytical standard of SPD304 (HY-111255). This product is intended for research and analytical applications. SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
Cat. No.: HY-P705083
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Spike; S protein; Spike glycoprotein; S glycoprotein; B.1.351; 20H/501Y.V2
Species:
Virus
Source:
HEK293
Cat. No.: HY-P705088
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Spike; S protein; Spike glycoprotein; S glycoprotein; B.1.617.2; 21A/S:478K
Species:
Virus
Source:
HEK293
Cat. No.: HY-P705090
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Spike; S protein; Spike glycoprotein; S glycoprotein; AY.1/AY.2/AY.3; Delta Plus
Species:
Virus
Source:
HEK293
Cat. No.: HY-174975
Target:
Research Areas:
JY-21 is a BRD4 PROTAC degrader active against both long and short BRD4 isoforms. JY-21 binds to TRIM28, RACK1, LMO7 and FUS to induce proteasomal degradation of BRD4 isoforms (DC50: 5.944 μM for long BRD4 isoform; 3.797 μM for short BRD4 isoform). JY-21 is applicable to research related to triple-negative breast cancer .
Cat. No.: HY-180547
CAS No.: 3070832-68-4
Target:
Research Areas:
MRC71 is a TRIMTAC degrader that recruits endogenous TRIM21 E3 ligase at one end and covalently binds to HaloTag-fusion target proteins at the other end. MRC71 selectively degrades oligomeric CAV1- and Cavin1-mEGFP-Halo, but not monomeric mEGFP-Halo, and exhibits a typical concentration-dependent degradation profile with a hook effect. MRC71 can be used to verify TRIMTAC ternary complex formation and state-selective degradation in cells .
Cat. No.: HY-175240
Target:
Research Areas:
PROTAC BRD4 Degrader-38 is a BRD4 PROTAC degrader with DC50 values of 86 nM and 106 nM against the short and long isoforms of BRD4, respectively. PROTAC BRD4 Degrader-38 covalently binds to the Cys232 residue of TRIM28 to form a ternary complex containing BRD4, thereby promoting the ubiquitination and degradation of BRD4. PROTAC BRD4 Degrader-38 can be used in the research of acute myeloid leukemia .
Cat. No.: HY-P705084
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Spike; S protein; Spike glycoprotein; S glycoprotein; B.1.1.7; 20I/501Y.V1; VOC 202012/01
Species:
Virus
Source:
HEK293
Cat. No.: HY-P12139
CAS No.: 117138-20-2
Target:
Research Areas:
GLFGAIAGFIENGWEGMIDG is an influenza hemagglutinin fusion peptide and membrane disruptor composed of 20 amino acids. GLFGAIAGFIENGWEGMIDG transiently adopts an activated double-helix conformation under low pH conditions; meanwhile, it self-assembles into oligomers with a stable trimeric core, which further form pentamers and hexamers capable of inducing membrane bending, thinning and long-range disruption. GLFGAIAGFIENGWEGMIDG promotes the protrusion of lipid tails and the penetration of polar heads in phospholipid membranes, and is widely used in influenza-related studies .
Target:
Research Areas:
PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41μM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors .
Cat. No.: HY-180129
CAS No.: 308293-08-5
SARS-CoV-2-IN-120 (Compound S22) is a SARS-CoV-2-specific entry inhibitor. SARS-CoV-2-IN-120 binds and trimerizes within the apex cavity of the SARS2 spike trimer. SARS-CoV-2-IN-120 blocks RBD-ACE2 interaction. SARS-CoV-2-IN-120 neutralizes BA.2 and subsequent Omicron variants. SARS-CoV-2-IN-120 inhibits SARS-CoV-2 replication in mice .
Cat. No.: HY-P992301
Cat. No.: HY-122204
CAS No.: 338962-32-6
5M038 is an inhibitor of HIV envelope-mediated fusion with potent inhibitory activity against gp41-mediated membrane fusion. 5M038 prevents the formation of the gp41 post-fusion conformation and inhibits envelope-mediated membrane fusion in cell-cell fusion and viral infectivity assays. 5M038 has shown broad fusion inhibition in tests against multiple HIV-1 subtypes, including M and T strains. 5M038 targets a highly conserved hydrophobic pocket and binds to the gp41 trimer, thereby exerting its inhibitory effect .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
