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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
250 Results for "
NP
" in MedChemExpress (MCE) Product Catalog:
Products (250)
250 Results for "NP" in MCE Product Catalog:
Cat. No.: HY-144668
CAS No.: 3035088-22-0
Target:
Research Areas:
RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice .
Cat. No.: HY-178281
CAS No.: 931928-13-1
Target:
Research Areas:
E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research .
Cat. No.: HY-181691
Target:
Research Areas:
JAK2-IN-20 is an orally active dual inhibitor targeting JAK2 kinase (IC50=49.17 nM) and influenza A virus PB2 protein (IC50=3.337 μM, Kd=2.82 μM). JAK2-IN-20 effectively blocks the JAK/STAT signaling pathway by reducing the phosphorylation levels of STAT1 and STAT3, thereby inhibiting viral replication and downregulating the expression of viral NP and PB2 proteins. In addition, JAK2-IN-20 significantly inhibits the mRNA expression of key inflammatory cytokines such as IL-6, TNF-α and IFN-β in inflammation and influenza infection models. JAK2-IN-20 serves as an important tool molecule for the study of influenza A virus infection and related pathologies .
Cat. No.: HY-B1735
CAS No.: 32828-81-2
Target:
Picotamide is an orally active TXA2 receptor and TXA2 synthase inhibitor. Picotamide inhibits ADP (HY-W010918)-, Arachidonic acid (HY-109590)-, and Collagen (HY-NP003)-induced platelet aggregation, reduces TXA2 production during coagulation, and does not inhibit PGI2 synthesis in endothelial cells. Picotamide inhibits contractions induced by α1-adrenergic receptor agonism, TXA2 mediation, and neurogenic (electrical field stimulation-induced) factors in human prostatic smooth muscle, and broadly inhibits agonist-induced contractions of porcine interlobar renal and coronary arteries. Picotamide can be used in research related to thromboembolic diseases, atherosclerosis, and lower urinary tract symptoms .
Cat. No.: HY-B1735A
CAS No.: 80530-63-8
Target:
Picotamide monohydrate is an orally active TXA2 receptor and TXA2 synthase inhibitor. Picotamide monohydrate inhibits ADP (HY-W010918)-, Arachidonic acid (HY-109590)-, and Collagen (HY-NP003)-induced platelet aggregation, reduces TXA2 production during coagulation, and does not inhibit PGI2 synthesis in endothelial cells. Picotamide monohydrate inhibits contractions induced by α1-adrenergic receptor agonism, TXA2 mediation, and neurogenic (electrical field stimulation-induced) factors in human prostatic smooth muscle, and broadly inhibits agonist-induced contractions of porcine interlobar renal and coronary arteries. Picotamide monohydrate can be used in research related to thromboembolic diseases, atherosclerosis, and lower urinary tract symptoms .
Cat. No.: HY-P74665
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PNP; Epididymis Secretory Sperm Binding Protein Li 156an; Prev. NP; Purine-Nucleoside Phosphorylase; Inosine-Guanosine Phosphorylase; Nucleoside Phosphorylase; Inosine Phosphorylase; HEL-S-156an; PUNP; PRO1837; Purine Nucleoside Phosphorylase; Purine-Nucl
Species:
Human
Source:
E. coli
Cat. No.: HY-P76710
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SMPD1; Niemann-Pick Type A/B; Sphingomyelin Phosphodiesterase 1; Sphingomyelin Phosphodiesterase 1 Isoform 7; Acid Sphingomyelinase; SMPD1 Protein; ASM; ASMASE; Sphingomyelin Phosphodiesterase; ASMase; Sphingomyelin Phosphodiesterase 1, Acid Lysosomal; NP
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703844
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P76134A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SMPD1; Niemann-Pick Type A/B; Sphingomyelin Phosphodiesterase 1; Sphingomyelin Phosphodiesterase 1 Isoform 7; Acid Sphingomyelinase; SMPD1 Protein; ASM; ASMASE; Sphingomyelin Phosphodiesterase; ASMase; Sphingomyelin Phosphodiesterase 1, Acid Lysosomal; NP
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P70401
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70185
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P73312
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78779
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P702534
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Rat
Source:
HEK293
Cat. No.: HY-108667
CAS No.: 61368-63-6
Research Areas:
TNP-ATP triethylammonium is a P2X receptor antagonist with an IC50 of 0.010 μM for P2X3 and an IC50 of 0.062 μM for P2X2/3. TNP-ATP triethylammonium acts as an inhibitor of CheA autophosphorylation, with a Ki of 0.7 µM. TNP-ATP triethylammonium blocks the functional activation of P2X1-7 receptors. TNP-ATP triethylammonium attenuates hypoxia-induced IL-1β expression and release. TNP-ATP triethylammonium alleviates visceral pain, and improves hypoxia-induced cognitive impairment, insufficient myelination and neuroinflammation. Binding of TNP-ATP triethylammonium to CheA enhances the fluorescence of the TNP group. TNP-ATP triethylammonium can be used in studies related to visceral pain. NP-ATP triethylammonium can be used in studies related to hypoxia-induced insufficient myelination and cognitive decline .
Cat. No.: HY-P72403
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P73309
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P73310
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; Transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-189215
CAS No.: 3087067-85-1
Target:
Influenza Virus RIG-I-like receptor (RLR) Toll-like Receptor (TLR) NF-κB Interleukin Related IFNAR Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Anti-Influenza agent 12 is an orally active inhibitor of influenza A virus infection. Anti-Influenza agent 12 inhibits RIG-I-mediated innate immune signaling and TLR3-mediated signaling pathways. Anti-Influenza agent 12 inhibits NF-κB phosphorylation and downregulates the expression levels of IRF3, ASC, iNOS, IL-4, IL-6, and IFN-α inflammatory genes. Anti-Influenza agent 12 inhibits viral nucleoprotein (NP) and matrix protein 2 (M2) mRNA transcription and protein synthesis. Anti-Influenza agent 12 inhibits virus-induced apoptosis, reduces ROS and NO production, and maintains mitochondrial membrane potential. Anti-Influenza agent 12 exhibits broad-spectrum activity against H1N1 and H3N2 subtypes, reduces viral load, and alleviates lung tissue damage. Anti-Influenza agent 12 can be used for research on influenza A virus infection .
Cat. No.: HY-P74692
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NPC2; Epididymal Protein 1; NPC Intracellular Cholesterol Transporter 2; NP-C2; HE1; Epididymis Secretory Sperm Binding Protein; EDDM1; Tissue-Specific Secretory Protein; Niemann-Pick Disease Type C2 Protein; Niemann-Pick Disease, Type C2; Human Epididymi
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
