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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
C481S
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "C481S" in MCE Product Catalog:
Cat. No.: HY-151211
CAS No.: 2883232-92-4
Target:
Research Areas:
BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC50s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia .
Cat. No.: HY-153951S
CAS No.: 2762043-61-6
Cat. No.: HY-144170
CAS No.: 2755843-62-8
RET-IN-14 (compound 49) is a potent RET inhibitor with IC50s of <0.51 nM, 9.3 nM, 1.3 nM, 9.2 nM, 15 nM for RET (WT), RET (G810R), RET (V804M), BTK and BTK (C481S), respectively. RET-IN-14 has the potential for tumors research
Cat. No.: HY-124153
CAS No.: 1433820-83-7
Target:
Research Areas:
GNE-431 is a potent, selective and noncovalent “pan-BTK” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK (IC50= 3.2 nM) and potency against C481S mutant (IC50= 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases .
Cat. No.: HY-160167A
CAS No.: 2662512-14-1
Synonyms: (R,R)-DZD8586
(R,R)-Birelentinib ((R,R)-DZD8586) (Compound 14) is a potent BTK inhibitor with IC50 values for BTK WT and BTK C481S of 0.7 and 0.86 nM, respectively. (R,R)-Birelentinib inhibits the self-phosphorylation of BTK and its IC50 is 24.3 nM. (R,R)-Birelentinib exhibits significant anti-proliferative activity against wild-type and C481S mutant HEK293 cells. (R,R)-Birelentinib can be used for the study of drug-resistant B-cell malignancies .
Cat. No.: HY-19834R
CAS No.: 1434048-34-6
Synonyms: GDC-0853 (Standard)
Target:
Research Areas:
Fenebrutinib (Standard) is the analytical standard of Fenebrutinib (HY-19834). This product is intended for research and analytical applications. Fenebrutinib (GDC-0853) is a potent, selective, orally available, and noncovalent bruton's tyrosine Kinase (Btk) inhibitor with Kis of 0.91 nM, 1.6, 1.3, 12.6, and 3.4 nM for WT Btk, and the C481S, C481R, T474I, T474M mutants. Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research .
Cat. No.: HY-P706147
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BTK; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Prev. AGMX1; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14); Prev. IMD1; Tyrosine-Protein Kinase BTK Isoform 52; ATK; Tyrosine-Protein Kinase BTK Isoform 51; PSCTK1; Tyrosine-Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702730
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BTK; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Prev. AGMX1; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14); Prev. IMD1; Tyrosine-Protein Kinase BTK Isoform 52; ATK; Tyrosine-Protein Kinase BTK Isoform 51; PSCTK1; Tyrosine-Protein
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
