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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
GEF
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "GEF" in MCE Product Catalog:
Cat. No.: HY-P1383A
Cat. No.: HY-175326
CAS No.: 2767633-04-3
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer .
Cat. No.: HY-P83137A
Synonyms: ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16
Cat. No.: HY-102078R
CAS No.: 303094-67-9
Target:
Research Areas:
ZINC69391 (Standard) is the analytical standard of ZINC69391 (HY-102078). This product is intended for research and analytical applications. ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects .
Cat. No.: HY-P1383
CAS No.: 1315378-77-8
Target:
Research Areas:
Cat. No.: HY-124755
CAS No.: 1579978-17-8
RAS activator compound 1 (Compound 7c) is a RAS activator targeting the guanine nucleotide exchange factor (GEF) son of sevenless homologue 1 (SOS1). RAS activator compound 1 can activate the nucleotide exchange process and increase levels of active RAS-GTP in HeLa cells. RAS activator compound 1 can be used for research of RAS-driven tumor .
Cat. No.: HY-P76353
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GABARAPL2; Golgi-Associated ATPase Enhancer Of 16 KDa; GABA Type A Receptor Associated Protein Like 2; General Protein Transport Factor P16; GATE-16; Ganglioside Expression Factor 2; GEF2; GEF-2; GATE16; GABA(A) Receptor-Associated Protein-Like 2, Isoform
Species:
Human
Source:
E. coli
Cat. No.: HY-P703253
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ARHGEF7; PAK3; Rho Guanine Nucleotide Exchange Factor 7; P50; P85SPR; Rho Guanine Nucleotide Exchange Factor (GEF) 7; COOL1; SH3 Domain-Containing Proline-Rich Protein; PIXB; DKFZp686C12170; P85; DKFZp761K1021; PAK-Interacting Exchange Factor Beta; COOL-1
Species:
Human
Source:
E. coli
Cat. No.: HY-186309
Research Areas:
ISRACT-01 is an integrated stress response (ISR) activator. ISRACT-01 has a Kd of 557 nM for eIF2B Δ-latch. ISRACT-01 cooperates with eIF2-P to inhibit guanine nucleotide exchange factor (GEF) activity by specifically binding to and stabilizing the inactive conformation (I-state) of eIF2B. ISRACT-01 can be used in studies related to amyotrophic lateral sclerosis .
Cat. No.: HY-110100R
CAS No.: 310460-39-0
Target:
Research Areas:
CPYPP (Standard) is the analytical standard of CPYPP (HY-110100). This product is intended for research and analytical applications. CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 μM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9 .
Cat. No.: HY-P71677
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FAM20C; Golgi-Enriched Fraction Casein Kinase; FAM20C Golgi Associated Secretory Pathway Kinase; IMAGE:4942737; DMP4; DKFZp547D065; Dentin Matrix Protein 4; GEF-CK; Golgi Casein Kinase; DMP-4; G-CK; FAM20C, Golgi Associated Secretory Pathway Kinase; Extra
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
