Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
59 Results for "
derivative of ATP
" in MedChemExpress (MCE) Product Catalog:
Products (59)
59 Results for "derivative of ATP" in MCE Product Catalog:
Cat. No.: HY-162142
CAS No.: 2226086-65-1
Research Areas:
BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM .
Cat. No.: HY-W017200
CAS No.: 13073-35-3
Synonyms: L-ETH
Target:
Research Areas:
L-Ethionine (L-ETH) is an amino acid derivative. L-Ethionine serves as a substrate for ATP:L-methionine S-adenosyltransferase, which targets its L-stereoisomer. L-Ethionine blocks the synthesis of N 6-dimethyladenosine in rat liver tRNA/4S RNA via its major hepatic metabolite S-adenosylethionine, inducing methyl-deficient rat liver tRNA/4S RNA. L-Ethionine can be used in studies of liver cancer and hepatocarcinogenesis mechanisms .
Cat. No.: HY-DY1043
CAS No.: 730931-46-1
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-A0176
CAS No.: 25046-79-1
Target:
Research Areas:
Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect .
Cat. No.: HY-DY1026
Solvent and concentration: DMSO: 1 mM
Cat. No.: HY-B0422S
CAS No.: 1227666-13-8
Synonyms: A4166 d5; Senaglinide d5
Cat. No.: HY-131831A
Synonyms: N6-benzyl ADP sodium
Target:
Research Areas:
6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) (HY-W010918) that inhibits ATP hydrolysis. 6-Bn-ADP sodium inhibits the ATPase activities of Mortalin, Hsc70, and Hsp70 protein with Kis of 86.51 μM, 294.5 μM, and 1612 μM, respectively .
Cat. No.: HY-12137R
CAS No.: 755038-65-4
Synonyms: BI 6727 (Standard)
Research Areas:
Volasertib (Standard) is the analytical standard of Volasertib. This product is intended for research and analytical applications. Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models .
Cat. No.: HY-W011428R
CAS No.: 101622-51-9
Target:
Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 μM), CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM) . Olomoucine regulates cell cycle and shows anti-melanin tumor activity .
Cat. No.: HY-131760
CAS No.: 61468-88-0
Synonyms: 2'-Amino-2'-deoxyadenosine-5'-triphosphate
Target:
Research Areas:
2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a Ki of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling .
Cat. No.: HY-157045
Target:
Research Areas:
ATP Synthesis-IN-1 (Compound 4), quinoline derivative, is a potent inhibitor of PA ATP synthesis activity. ATP Synthesis-IN-1 has PA ATP synthesis inhibition with IC50 value of 11.1μg/mL. ATP Synthesis-IN-1 also has antibacterial activity. ATP Synthesis-IN-1 can be used for the research of drug-resistant PA infection .
Cat. No.: HY-134372A
Target:
Research Areas:
Bis-Br-ANT-ATP (tetrasodium) is a fluorescent derivative of adenosine-5’-triphosphate (ATP) (HY-B2176). Bis-Br-ANT-ATP (tetrasodium) selectively inhibits B. pertussis adenylyl cyclase toxin CyaA (Ki: 12.6 nM). Bis-Br-ANT-ATP (tetrasodium) can be used in Whooping cough research .
Cat. No.: HY-134373A
Target:
Research Areas:
Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (Kis = 16, 1,700, 2,400, and 1,600 nM, respectively). Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough .
Cat. No.: HY-160124
CAS No.: 2504949-83-9
Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor .
Cat. No.: HY-134272A
CAS No.: 1188369-62-1
Synonyms: 8-Bromo-dATP tetrasodium
Target:
Research Areas:
8-Bromo-2'-deoxy-ATP (8-Bromo-dATP) tetrasodium is a derivative of the nucleoside triphosphate 2'-Deoxyadenosine-5'-triphosphate (dATP, HY-136648).
Cat. No.: HY-12283R
CAS No.: 156722-18-8
Synonyms: PST 2238 (Standard)
Target:
Research Areas:
Rostafuroxin (Standard) is the analytical standard of Rostafuroxin. This product is intended for research and analytical applications. Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity .
Cat. No.: HY-165363
CAS No.: 75397-64-7
Research Areas:
AK-135 hydrochloride is a Menadione (HY-B0332) derivative. AK-135 hydrochloride restores the electron flow in defective respiratory chain systems. AK-135 hydrochloride decreases LDH release, increases the amount of ATP. AK-135 hydrochloride has a protective effect against myocardial injury .
Cat. No.: HY-168572
CAS No.: 2944457-11-6
MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain .
Cat. No.: HY-B0422R
CAS No.: 105816-04-4
Synonyms: A4166 (Standard); Senaglinide (Standard)
Research Areas:
Nateglinide (Standard) is the analytical standard of Nateglinide. This product is intended for research and analytical applications. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K + channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus .
Cat. No.: HY-134033A
Synonyms: 2'-Fluoro dATP sodium
Target:
Research Areas:
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176). 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
