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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
62 Results for "
selectins
" in MedChemExpress (MCE) Product Catalog:
Products (62)
62 Results for "selectins" in MCE Product Catalog:
Art. -Nr.: HY-P99443
CAS. Nr.: 395639-53-9
Synonyms: HuDreg-55
Target:
Forschungsgebiete:
Art. -Nr.: HY-P10887
CAS. Nr.: 2988012-71-9
Synonyms: AV-001
Target:
Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin
Forschungsgebiete:
Art. -Nr.: HY-122655
CAS. Nr.: 2002363-68-8
Target:
Forschungsgebiete:
HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice .
Art. -Nr.: HY-146332
CAS. Nr.: 104260-73-3
Target:
Forschungsgebiete:
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .
Art. -Nr.: HY-P990201
Target:
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Art. -Nr.: HY-177800
Target:
Forschungsgebiete:
ARC5690 sodium is an anti-mouse P-selectin aptamer. ARC5690 bound to recombinant mouse P-selectin with a KD of approximately 15pM in vitro. ARC5690 showed a significant anti-inflammatory effect
Art. -Nr.: HY-E70303
CAS. Nr.: 2178088-82-7
Synonyms: FUT6
Target:
Forschungsgebiete:
Fucosyltransferase 6 is a fucosyltransferase that mediates the expression of the tetrasaccharide Sialyl-Lewis x (sLex, CD15s) on the surface of leukocytes. sLex participates in E-selectin-mediated leukocyte rolling and is related to the migration of leukocytes out of blood vessels .
Art. -Nr.: HY-W854385
CAS. Nr.: 92448-22-1
Synonyms: SLeA
Target:
Forschungsgebiete:
Sialyl Lewis A (SLeA) is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .
Art. -Nr.: HY-106139A
CAS. Nr.: 187269-60-9
Synonyms: TBC-1269Z
Target:
Forschungsgebiete:
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects .
Art. -Nr.: HY-N1480S1
CAS. Nr.: 83379-37-7
Synonyms: 6-Desoxygalactose-13C-1; L-(-)-Fucose-13C-1; L-Galactomethylose-13C-1
Art. -Nr.: HY-N0250R
CAS. Nr.: 20874-52-6
Art. -Nr.: HY-158459
Synonyms: A2G2F2(a1-3) glycan
Art. -Nr.: HY-P990847
Target:
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Art. -Nr.: HY-P9987A
CAS. Nr.: 1690318-25-2
Target:
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Art. -Nr.: HY-106139R
CAS. Nr.: 187269-40-5
Synonyms: TBC-1269 (Standard)
Target:
Forschungsgebiete:
Bimosiamose (Standard) is the analytical standard of Bimosiamose. This product is intended for research and analytical applications. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
Art. -Nr.: HY-160072
CAS. Nr.: 1194666-63-1
Target:
Forschungsgebiete:
Fmoc-NH-PEG2-NHS ester is an intermediate used in the synthesis of E-selectin antagonists [1] .
Art. -Nr.: HY-119158
CAS. Nr.: 1476847-58-1
Forschungsgebiete:
VU0652925, an analog of BMS986120, is a PAR4 antagonist, with IC50 values of 43 pM and 39.2 pM for PAC1 and P-selectin, respectively. VU0652925 is able to suppress GPIIbIIIa activation .
Art. -Nr.: HY-N1480S
CAS. Nr.: 83379-38-8
Synonyms: 6-Desoxygalactose-13C; L-(-)-Fucose-13C; L-Galactomethylose-13C
Art. -Nr.: HY-N1480S2
CAS. Nr.: 478518-50-2
Synonyms: 6-Desoxygalactose-13C-2; L-(-)-Fucose-13C-2; L-Galactomethylose-13C-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
