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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
Ca2 binding
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "Ca2 binding" in MCE Product Catalog:
Cat. No.: HY-N2359
CAS No.: 34316-15-9
Category:
Alkaloids Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Papaveraceae
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Cat. No.: HY-142117
CAS No.: 149091-92-9
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Adenophostin A is an IP3 receptor (inositol 1,4,5-trisphosphate receptors) modulator and Ca 2+ releaser, with an IC50 of 1.3 nM, an EC50 of 1.4 nM, and a Ki of 0.18 nM in rats, and an IC50 of 0.95 nM in humans. Adenophostin A activates IP3 receptors, stimulates Ca 2+ release from intracellular stores and microsomes, inhibits the binding of [ 3H]IP3 to plasma membrane receptors, and activates chloride channels. Adenophostin A resists phosphorylation and dephosphorylation by IP3 metabolic enzymes to maintain its activity, and increases cytoplasmic [Ca 2+] levels via calcium mobilization from the endoplasmic reticulum of vascular smooth muscle cells. Adenophostin A is applicable to research related to hemorrhagic shock .
Cat. No.: HY-N6688
CAS No.: 12771-72-1
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SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .
Cat. No.: HY-P5506
CAS No.: 144555-23-7
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Cat. No.: HY-P1805
CAS No.: 104041-80-7
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TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca 2+ .
Cat. No.: HY-W041308
CAS No.: 64359-81-5
Synonyms: Kathon 930
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DCOIT (Kathon 930) is an isothiazolinone biocide and environmental pollutant that directly binds to G protein α subunits, with KD values of 0.92 mM and 0.4 mM for Gαs and Gαi, respectively. Binding of DCOIT to Gαi enhances the interaction between Gαi and mitochondrial calcium uniporter (MCU), alters the subcellular distribution of intracellular Ca 2+, and activates PKC/MEK/ERK signaling. DCOIT upregulates CYP19a transcription and aromatase activity, thereby disrupting steroid hormone homeostasis. DCOIT is used in studies of reproductive endocrine disruption and environmental toxicology .
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PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
Cat. No.: HY-D1631A
CAS No.: 153130-66-6
Cat. No.: HY-P1076A
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Cat. No.: HY-NP164B
Synonyms: Con A-AF488
Cat. No.: HY-D1608
CAS No.: 216571-99-2
Cat. No.: HY-175593
CAS No.: 696628-90-7
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M6766 is a selective endoplasmic reticulum oxidoreductase 1α (ERO1α) inhibitor with an IC50 of 1.4 μM and a KD of 1.1 μM. M6766 also inhibits ERO1β with an IC50 of 7.2 μM. M6766 binds to the flavin adenine dinucleotide-binding pocket in ERO1α. M6766 inhibits granule secretion, αIIbβ3 integrin activation, Ca 2+ mobilization, and platelet aggregation. M6766 can be used for the research of neurological disease, such as ischemic stroke .
Cat. No.: HY-N0215S14
Synonyms: (S)-2-Amino-3-phenylpropionic acid-15N,d8
Cat. No.: HY-D0157
CAS No.: 321859-11-4
Cat. No.: HY-P5436
CAS No.: 99268-57-2
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Cat. No.: HY-D1759
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Fura-4F AM is a fluorescent dye used for detecting intracellular free calcium concentration ([Ca 2+]ᵢ). Fura-4F AM is cell membrane-permeable; after entering cells, it is hydrolyzed by intracellular esterases to form Fura-4F, and reflects changes in intracellular Ca 2+ concentration through Ca 2+ binding-dependent fluorescence changes, making it suitable for rapid detection of high-concentration Ca 2+ signals (Ex = 385 nm) .
Cat. No.: HY-126821
CAS No.: 123632-39-3
Cat. No.: HY-P5988
CAS No.: 152246-40-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
