61 Results for "

RAP1

" in MedChemExpress (MCE) Product Catalog:
Products (61)

61 Results for "RAP1" in MCE Product Catalog:

Cat. No.: HY-B0627S1
Synonyms: 1,1-Dimethylbiguanide-13C2 hydrochloride
Metformin- 13C2 (1,1-Dimethylbiguanide- 13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
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Cat. No.: HY-RS16300
Research Areas:  

Cancer

Rap1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rap1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11652
Research Areas:  

Others

RAP1A Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P10038
CAS No.: 2700321-79-3
Synonyms: Myr-FEEERA-OH
Target:  

Integrin

Research Areas:  

Infection

mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells [1].
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Cat. No.: HY-123242A
CAS No.: 2820151-01-5
Purity:  99.11%
Target:  

Farnesyl Transferase

Research Areas:  

Cancer

FTI-2153 TFA is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 TFA is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity [1].
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Cat. No.: HY-120271
CAS No.: 181045-83-0
Target:  

Ras

Research Areas:  

Cancer

GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras [1] .
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Cat. No.: HY-186198
CAS No.: 1092521-71-5
Synonyms: Salirasib methoxymethyl ester
Target:  

Ras

Research Areas:  

Others

FTS-MOM (Salirasib methoxymethyl ester), a Salirasib (FTS) (HY-14754) derivative, is a selective Rap1 inhibitor with selectivity over Ras. FTS-MOM inhibits GTP loading of Rap1 in quiescent and activated T cells. FTS-MOM inhibits Rap1-dependent T cell adhesion to ICAM-1 [1].
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Cat. No.: HY-RS11653
Research Areas:  

Others

RAP1B Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11654
Research Areas:  

Others

RAP1GAP Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16301
Research Areas:  

Cancer

Rap1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rap1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11655
Research Areas:  

Others

RAP1GAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11656
Research Areas:  

Others

RAP1GDS1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1GDS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS02389
Research Areas:  

Others

CDK5RAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5RAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-N0657R
CAS No.: 63902-38-5
Pinoresinol Diglucoside (Standard) is the analytical standard of Pinoresinol Diglucoside (HY-N0657). This product is intended for research and analytical applications. Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis.
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Cat. No.: HY-P82081
Synonyms: RAP1GAP; KIAA0474; RAP1GA1; RAP1 GTPase-activating protein 1; RAP1GAP; RAP1GAP1

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P82081A
Synonyms: RAP1GAP; KIAA0474; RAP1GA1; RAP1 GTPase-activating protein 1; RAP1GAP; RAP1GAP1

Host:  

Rabbit

Application:  

WB, IHC-F, IHC-P, ICC/IF, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-RS14374
Research Areas:  

Others

TERF2IP Human Pre-designed siRNA Set A contains three designed siRNAs for TERF2IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS11586
Research Areas:  

Others

RABGEF1 Human Pre-designed siRNA Set A contains three designed siRNAs for RABGEF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-180801
CAS No.: 2419580-01-9
E8431 is a DCSTAMP antagonist with an IC50 value of 775.8 nM for osteoclastogenesis. E8431 selectively binds to the endoplasmic reticulum domain of DCSTAMP, disrupts its interaction with RAP1B, and inhibits downstream cytoskeleton rearrangement mediated by the RAP1-RAC1 signaling pathway, thereby impeding osteoclast precursor fusion, suppressing bone resorption, and stimulating PDGFBB secretion to promote osteogenesis and angiogenesis. E8431 can be used in the research of osteoporosis [1].
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Cat. No.: HY-P810838
Synonyms: DRIP5; RAP1; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRAP1

Host:  

Mouse

Application:  

WB

Reactivity:  

Human, Mouse

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