208 Results for "

extend

" in MedChemExpress (MCE) Product Catalog:
Products (208)

208 Results for "extend" in MCE Product Catalog:

2
2 Cited Publications
製品番号: HY-148559
CAS 番号: 1857340-78-3
純度:  99.21%
Target:  

Liposome

研究分野:  

Cancer

4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model .
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2
2 Cited Publications
製品番号: HY-N0925
CAS 番号: 522-97-4
別名: Canadine
Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach .
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2
2 Cited Publications
製品番号: HY-100591
CAS 番号: 709002-46-0
純度:  ≥99.0%
SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration .
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2
2 Cited Publications
製品番号: HY-133968
CAS 番号: 474-63-5
純度:  99.48%
別名: Ostreasterol
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .
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2
2 Cited Publications
製品番号: HY-106257A
CAS 番号: 1628046-32-1
純度:  98.17%
Target:  

Bacterial Antibiotic

研究分野:  

Infection

Ceftolozane TFA is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane TFA acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane TFA can be used in studies related to bacterial infections .
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2
2 Cited Publications
製品番号: HY-19806A
CAS 番号: 936111-69-2
別名: CXA-101; FR264205
Target:  

Bacterial Antibiotic

研究分野:  

Infection

Ceftolozane sulfate is a cephalosporin antibiotic active against Gram-negative pathogens. Ceftolozane sulfate acts as a bactericide and reduces Klebsiella pneumoniae thigh tissue loads in neutropenic mice. Ceftolozane sulfate can be used in studies related to bacterial infections .
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1
1 Cited Publications
製品番号: HY-139411
CAS 番号: 8042-47-5
別名: Paraffin oil
White mineral oil is the highly refined mineral oil, and is composed of saturated aliphatic and alicyclic nonpolar hydrocarbons. White mineral oil is biologically and chemically stable, and doesn’t support pathogenic bacterial growth. White mineral oil can resist moisture, extend, soften, smoothen, and lubricate .
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1
1 Cited Publications
製品番号: HY-P99350
CAS 番号: 2413817-97-5
別名: AMG 910; Anti-Human CD3xClaudin18 2

Target:  

CD3

研究分野:  

Cancer

Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and CLDN18.2-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma .
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1
1 Cited Publications
製品番号: HY-P99814
CAS 番号: 2250292-39-6
別名: AMG-701

Target:  

CD3

研究分野:  

Inflammation/Immunology Cancer

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM) .
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1
1 Cited Publications
製品番号: HY-N0723
CAS 番号: 64809-67-2
Neomangiferin is an orally active natural flavonoid. Neomangiferin partially ameliorates non-alcoholic fatty liver disease (NAFLD) by regulating the expression of genes related to free fatty acid uptake and lipid oxidation. Neomangiferin exerts anti-colitis effects by inhibiting Th17/Treg cell differentiation. Neomangiferin exerts anti-aging and lifespan-extending effects by targeting upregulation of bas-1, which in turn activates the autophagy, IIS and MAPK pathways. Neomangiferin has the potential to prevent aseptic loosening of prostheses after total joint arthroplasty due to its significant anti-inflammatory and osteoclastogenesis-inhibiting effects .
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1
1 Cited Publications
製品番号: HY-N6924
CAS 番号: 80930-74-1
Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection .
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製品番号: HY-42990
CAS 番号: 97281-48-6
別名: HSPC; Hydrogenated soybean phosphatidylcholine
Target:  

Liposome

研究分野:  

Metabolic Disease

Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) is a natural product. Hydrogenated soya phosphatidylcholine can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs .
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製品番号: HY-N2598
CAS 番号: 112-62-9
Methyl oleate is a fatty acid methyl ester (FAME) with anti-extended spectrum β-Lactamase (ESBL) potential, anticancer and antibacterial activities. Methyl oleate substantially improves the antioxidation ability but markedly impaired the antiwear capacity of zinc dialkyldithiophosphate (ZDDP). Methyl oleate is promising for research of ESBL producing multi drug resistant (MDR) pathogens .
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製品番号: HY-B0810A
CAS 番号: 32887-03-9
別名: FL-1039 hydrochloride
Target:  

Bacterial Antibiotic

研究分野:  

Infection

Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic.
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製品番号: HY-144004A
CAS 番号: 474922-22-0
純度:  ≥95.0%
別名: DSPE-PEG5000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] ammonium
Target:  

Liposome

研究分野:  

Others

DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents . DSPE-PEG5000-Mal ammonium contains PEG5000.
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製品番号: HY-120118
CAS 番号: 1443414-10-5
純度:  99.90%
別名: ML246
Target:  

DNA/RNA Synthesis

研究分野:  

Cancer

Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models .
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製品番号: HY-D1725
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .
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製品番号: HY-D1742
DeepRed Nucleus Dye is a novel cell permeant and far red-fluorescing DNA probe. DeepRed Nucleus Dye excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DeepRed Nucleus Dye fluorescence reflects cellular DNA content. DeepRed Nucleus Dye can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .
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製品番号: HY-B1466
CAS 番号: 42057-22-7
別名: BAY-f 1353 sodium
Target:  

Bacterial Antibiotic

研究分野:  

Infection

Mezlocillin (BAY-f 1353) sodium is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin sodium is active against both gram-negative and gram-positive bacteria. Mezlocillin sodium can be used in bacterial infection research .
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製品番号: HY-P99671
CAS 番号: 2254082-79-4
別名: M-6495

Target:  

ADAMTS

研究分野:  

Inflammation/Immunology

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life .
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