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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
73 Results for "
pH sensitive
" in MedChemExpress (MCE) Product Catalog:
Products (73)
73 Results for "pH sensitive" in MCE Product Catalog:
Cat. No.: HY-W094214
CAS No.: 7338-27-4
Synonyms: β-Methyl itaconate
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Monomethyl itaconate (β-Methyl itaconate) is a monomethyl ester derivative of Itaconic acid (HY-Y0520). Monomethyl itaconate can copolymerize with PEGMA to form pH-sensitive hydrogels .
Cat. No.: HY-DY1071
CAS No.: 312961-83-4
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-160113E
Cat. No.: HY-D2482
CAS No.: 1369302-18-0
Synonyms: APG-1 AM
Cat. No.: HY-D1556
CAS No.: 384832-91-1
Synonyms: 1,2-dioleoyl-sn-glycero-3-pHospHoethanolamine-N-(carboxyfluorescein) ammonium
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18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .
Cat. No.: HY-P5405
Synonyms: Transducible TAT-HA fusogenic peptide
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Cat. No.: HY-P5423A
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Cat. No.: HY-20794
CAS No.: 41175-50-2
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8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .
Cat. No.: HY-E70565
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O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus.
The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn 2+.
The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn 2+.
Cat. No.: HY-D1463
CAS No.: 699018-10-5
Cat. No.: HY-147104
CAS No.: 1095493-05-2
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Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye .
Cat. No.: HY-D2771
CAS No.: 2131079-93-9
Cat. No.: HY-D2817
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FITC-PLL is a fluorescently labeled polycationic polypeptide probe composed of polylysine (PLL) and FITC (HY-66019), with a typical Ex/Em of 495/520 nm. The fluorescence intensity and lifetime of FITC-PLL are sensitive to pH and FITC density. FITC-PLL can be used for quantifying hapten receptor binding and endocytosis kinetics in macrophages, as a patternable substrate for neuron guidance, for negatively charged phospholipid membrane binding and transmembrane transport, and for live-cell imaging of starch nanoparticle conjugates and lysosome labeling .
Cat. No.: HY-156514
CAS No.: 2987938-97-4
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MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody drug conjugates (ADC). MC-GGFG-AM-(10NH2-11F-Camptothecin) binds to the anti-TROp-2 antibody sacituzumab via a hydrolysable pH-sensitive linker and has anti-tumor activity. MC-GGFG-AM-(10NH2-11F-Camptothecin) can be used for cancer research .
Cat. No.: HY-176518
CAS No.: 2247153-41-7
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ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research .
Cat. No.: HY-D1470
CAS No.: 210832-86-3
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BADAN is a thiol-reactive, environment-sensitive fluorescent probe used for site-specific labeling of protein cysteine residues to detect protein topology, local polarity, protein-lipid interactions, and conformational changes. The bromoacetyl group of BADAN covalently binds to cysteine thiols, and its fluorescence originates from the intramolecular charge transfer (ICT) excited state. The emission peak position varies with the polarity of the surrounding medium: it blue-shifts to approximately 488 nm in nonpolar environments (such as the hydrophobic core of lipid bilayers) and red-shifts to approximately 496-507 nm in polar environments (such as aqueous phases), independent of enzymes, pH, or membrane potential. Ex = 380-402 nm; Em = 400-600 nm .
Cat. No.: HY-P2815
CAS No.: 37289-15-9
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Creatinine deiminase is a hydrolytic enzyme. Creatinine deiminase plays a crucial role in the conversion of the metabolic waste creatinine into creatine. Creatinine deiminase is a creatine bioanalytical tool. Creatinine deiminase can be used to construct a novel creatinine-sensitive biosensor when adsorbed on a silicate-modified pH-sensitive field-effect transistor (pH-FET) .
Cat. No.: HY-W110780
CAS No.: 845-10-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
