77 Results for "

CD44

" in MedChemExpress (MCE) Product Catalog:
Products (77)

77 Results for "CD44" in MCE Product Catalog:

Cat. No.: HY-P5352
CAS No.: 299157-43-0
Target:  

CD44

Research Areas:  

Inflammation/Immunology Cancer

Hyaluronan-IN-1 (Pep-1) is a Hyaluronan inhibitor with a Kd value of 1.65 μM. Hyaluronan-IN-1 blocks CD44-dependent cell adhesion. Hyaluronan-IN-1 inhibits cell adhesion to hyaluronan substrates. Hyaluronan-IN-1 suppresses the development of contact hypersensitivity in mice by blocking the homing process of inflammatory cells to the skin. Hyaluronan-IN-1 also inhibits responses during the sensitization phase. Hyaluronan-IN-1 reduces lung metastasis of melanoma and prolongs the survival of mice. Hyaluronan-IN-1 can be used in research related to contact hypersensitivity, chronic skin inflammation, and melanoma .
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Cat. No.: HY-165606
CAS No.: 178250-23-2
Target:  

Oct3/4 c-Myc Apoptosis

Research Areas:  

Cancer

SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 +/CD44 + cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers .
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Cat. No.: HY-D2836E
Synonyms: FITC-Hyaluronate (MW 10000)
FITC-HA (MW 10000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM) .
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Cat. No.: HY-D2836A
Synonyms: FITC-Hyaluronate (MW 500000)
FITC-HA (MW 500000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM) .
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Cat. No.: HY-D2836J
Synonyms: FITC-Hyaluronate (MW 3000)
FITC-HA (MW 3000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM) .
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Cat. No.: HY-164480
CAS No.: 1588866-45-8
Target:  

IKK NF-κB

Research Areas:  

Inflammation/Immunology Cancer

GTCpFE inhibits IKKα/β in the NF-κB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44 + CD24 - immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFκB- and PGE2-dependent phenotype in aggressive cancers .
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Cat. No.: HY-122585
CAS No.: 2138321-18-1
Target:  

MMP Src FAK

Research Areas:  

Cancer

proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX) .
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Cat. No.: HY-P992437

Target:  

CD44 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PF-03475952 is a fully human IgG2 monoclonal antibody targeting CD44. PF-03475952 binds an epitope in CD44’s constant exons, blocks CD44-hyaluronic acid interaction, reduces cell surface CD44, and does not cross-react with rodent CD44 or LYVE-1. PF-03475952 induces cancer cell apoptosis, inhibits LPS (HY-D1056)-induced leukocyte cytokine release and cancer metastasis, and reduces CD44 expression on circulating CD3+ lymphocytes in cynomolgus monkeys. PF-03475952 can be used for the research of rheumatoid arthritis and hepatocellular carcinoma .
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Cat. No.: HY-P700966
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700439
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P700967
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P12263
CAS No.: 288307-57-3
Target:  

CD44

Research Areas:  

Inflammation/Immunology Cancer

A5G27 is a laminin-derived peptide ligand and CD44 antagonist that binds to CD44, CD44v3, and CD44v6, driving receptor-mediated endocytosis and internalization into CD44-expressing cells. A5G27 alleviates mechanical hyperalgesia induced by substances such as carrageenan and Hyaluronidase. A5G27 exhibits antitumor activity. A5G27 can be used in research on cancer, inflammatory pain, and wound healing .
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Cat. No.: HY-P74291
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P74293
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700402
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P8F060A
Synonyms: CD44,CD44-FITC,IM7

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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Cat. No.: HY-P8F060C
Synonyms: CD44,CD44-PE,IM7

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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Cat. No.: HY-P8F060I
Synonyms: CD44,CD44-APC,IM7

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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Cat. No.: HY-P8F060K
Synonyms: CD44,CD44-AF700,IM7

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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Cat. No.: HY-P8F060L
Synonyms: CD44,CD44-PC Blue,IM7

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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