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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
LAT
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "LAT" in MCE Product Catalog:
Cat. No.: HY-RS27880
Target:
Research Areas:
Lat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P81297AA
Synonyms: LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
Cat. No.: HY-189122
CAS No.: 2251130-98-8
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Lpi-1 is an ATP-competitive LATS1/2 inhibitor with IC50 values of 4.4 nM and 1.3 nM, respectively. Lpi-1 blocks LATS-mediated YAP1 phosphorylation. Lpi-1 reversibly inhibits LATS1/2 in cells and in vivo, activating the YAP/TAZ signaling pathway. Lpi-1 can be used for research on acute liver injury and colitis .
Cat. No.: HY-164401A
CAS No.: 1802735-31-4
Research Areas:
QBS10072S dihydrochloride is a LAT1-selective substrate with blood-brain barrier permeability that inhibits tumor growth. QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces interstrand DNA cross-linking and cell apoptosis, and reduces leptomeningeal dissemination. QBS10072S dihydrochloride can be used in studies related to glioblastoma multiforme, diffuse intrinsic pontine glioma, triple-negative breast cancer brain metastases, and aggressive T-cell lymphoma .
Cat. No.: HY-138489R
CAS No.: 1424635-83-5
Synonyms: LATs-IN-1 (Standard)
Research Areas:
TRULI (Standard) is the analytical standard of TRULI (HY-138489). This product is intended for research and analytical applications. TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 Kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .
Cat. No.: HY-RS17343
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Lats1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187678
CAS No.: 3024011-79-5
Research Areas:
NCGC-023 is a LATS1/2 inhibitor. NCGC-023 selectively inhibits LATS1/2, an upstream regulator of Yap in the Hippo signaling pathway, increases the expression of active Yap protein, activates Yap-dependent signaling pathways, triggers non-Yap-dependent metallothionein-mediated heavy metal responses, and upregulates IL-33-related regenerative responses. NCGC-023 can be used in studies related to gastrointestinal acute radiation syndrome (GI-ARS) .
Cat. No.: HY-W267524
CAS No.: 14464-68-7
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H-Phe (3-CF3)-OH is a phenylalanine derivative targeting the L-type amino acid transporter 1 (LAT1, SLC7A5) as its core target, and it belongs to LAT1 substrates. H-Phe (3-CF3)-OH can be used for prodrug scaffold development and research related to multiple solid tumors .
Cat. No.: HY-183513
CAS No.: 2941355-27-5
L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT) .
Cat. No.: HY-182254
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AChE/BChE-IN-35, Tacrine (HY-111338) derivative, is a brain-penetrant dual AChE/BChE inhibitor with an Electric Eel AChE IC50 of 123.66 nM, human AChE IC50 of 122.34 nM, and equine BChE IC50 of 488.00 nM. AChE/BChE-IN-35 undergoes LAT1-mediated active transport across cell membranes. AChE/BChE-IN-35 exhibits enhanced brain exposure with slower brain tissue elimination. AChE/BChE-IN-35 can be used for the research of alzheimer's disease .
Cat. No.: HY-14889
CAS No.: 222727-43-7
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Fluciclovine is an amino acid analogue that can enter cells by targeting the amino acid transporters on the cell surface (mainly ASCT2 and LAT1). After being labeled with ¹⁸F, ¹⁸F-fluciclovine can be used as an imaging agent for positron emission tomography (PET) for prostate diagnosis imaging .
Cat. No.: HY-181743A
Research Areas:
Piezo1 agonist 2 hydrochloride is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 hydrochloride releases Jedi2 in mice. Piezo1 agonist 2 hydrochloride can be used for the research of neurodegenerative diseases .
Cat. No.: HY-181743
CAS No.: 3124796-49-9
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Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases .
Cat. No.: HY-150042R
CAS No.: 2687970-96-1
Research Areas:
TDI-011536 (Standard) is the analytical standard of TDI-011536 (HY-150042). This product is intended for research and analytical applications. TDI-011536 is a potent Lats Kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
