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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
Retina
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "Retina" in MCE Product Catalog:
Cat. No.: HY-100714R
CAS No.: 76326-31-3
Synonyms: 2-APV (Standard); DL-2-Amino-5-phosphonovaleric acid (Standard)
Target:
Research Areas:
DL-AP5 (Standard) is the analytical standard of DL-AP5. This product is intended for research and analytical applications. DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina .
Cat. No.: HY-169115A
CAS No.: 313651-02-4
Target:
Research Areas:
(Rac)-PD0299685 is a Ca(2+) channel α2δ ligand that was investigated for relieving interstitial cystitis pain in a randomized, double-blind, placebo-controlled phase IIa study. (Rac)-PD0299685 demonstrated a clinically significant reduction in daily worst pain severity scores at the 60 mg dose compared to placebo. (Rac)-PD0299685 is also a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.
Cat. No.: HY-117057
CAS No.: 105528-06-1
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Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C.
Cat. No.: HY-17357R
CAS No.: 78281-72-8
Synonyms: AHR 9434 (Standard); AL 6515 (Standard)
Research Areas:
Neurological Disease Inflammation/Immunology Endocrinology Cancer
Nepafenac (AHR 9434; AL 6515) (Standard) is the analytical standard of Nepafenac (HY-17357). This product is intended for research and analytical applications. Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.
Cat. No.: HY-N0637AR
CAS No.: 4049-38-1
Synonyms: (±)-Huazhongilexone (Standard); Dihydroluteolin (Standard)
Cat. No.: HY-W015422R
CAS No.: 5154-02-9
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1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina .
Cat. No.: HY-W014180R
CAS No.: 39145-52-3
Cat. No.: HY-185132
CAS No.: 3086854-73-8
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Research Areas:
RBP4-IN-2 (Compound 14) is a RBP4 inhibitor. RBP4-IN-2 can reduce RBP4 in mouse plasma by more than 50%. RBP4-IN-2 can be used to study diseases where excessive lipofuscin accumulates in the retina .
Cat. No.: HY-119059
CAS No.: 946249-82-7
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CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration .
Cat. No.: HY-108298R
CAS No.: 306-94-5
Synonyms: PP 5 (Standard); Perfluorodecahydronaphthalene (Standard)
Research Areas:
Perfluorodecalin (Standard) is the analytical standard of Perfluorodecalin (HY-108298). This product is intended for research and analytical applications. Perfluorodecalin liquids are largrly used in vitreoretinal surgery. Perfluorodecalin with tamponade lasting more than two days is detrimental to the retina in the case of rabbit. Perfluorodecalin can be used for the research of giant retinal tears . Perfluorodecalin is a non-toxic, non-flammable, thermally stable, non-bio-accumulating O2-carrier and used as artificial blood . Perfluorodecalin enhances bone regeneration and cell viability .
Cat. No.: HY-P992142
CAS No.: 3050549-24-8
Synonyms: ANX-007
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Cat. No.: HY-P71781
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SAG; Retinal S-Antigen; S-Antigen Visual Arrestin; Rod Arrestin; Rod Photoreceptor Arrestin; Arrestin 1; 48 KDa Protein; ARRESTIN; S-Arrestin; S-AG; RP47; Retinal S-Antigen (48 KDa Protein); S-Antigen; Retina And Pineal Gland (Arrestin); RP96
Species:
Human
Source:
P. pastoris
Cat. No.: HY-180889
CAS No.: 2257497-15-5
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Research Areas:
PROTAC BRD3 degrader-1 (compound D072) is a potent and selective PROTAC BRD3 degrader. PROTAC BRD3 degrader-1 selectively degrades BRD3 in mice, leading to the downregulation of H3K18ac without affecting BRD2 or BRD4. PROTAC BRD3 degrader-1 reduces intraocular inflammation in the experimental autoimmune uveitis (EAU) mouse mode and inhibits proinflammatory microglia in both uveitis retina and LPS (HY-D1056) treated mouse microglia cell line BV2. PROTAC BRD3 degrader-1 can be used for uveitis research .
Cat. No.: HY-184986
CAS No.: 2901868-37-7
Research Areas:
PIPE-791 is an orally active, blood-brain barrier-permeable selective antagonist of LPAR1. PIPE-791 inhibits LPA-induced calcium mobilization, collagen expression, histamine release, and the activation of fibroblasts, microglia and macrophages. PIPE-791 induces oligodendrocyte precursor cell differentiation, myelination and remyelination, and increases the number of microglia in the retina of normotensive rats. PIPE-791 protects mature oligodendrocytes from cytokine-induced death, reduces the levels of pulmonary fibrosis markers and alleviates neuroinflammation in preclinical models. PIPE-791 can be used in the research of glaucoma, neuroinflammatory diseases, chronic osteoarthritis pain, idiopathic pulmonary fibrosis and multiple sclerosis .
Cat. No.: HY-P76944
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: GUCA1A; GCAP-1; Prev. C6orf131; Cone Dystrophy 3; Prev. GUCA1; DJ139D8.6; Prev. GUCA; Guanylate Cyclase-Activating Protein, Photoreceptor 1; GCAP1; Guanylate Cyclase Activator 1A (Retina); GCAP; Chromosome 6 Open Reading Frame 131; Guanylyl Cyclase-Activa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P76945
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GUCA1A; GCAP-1; Prev. C6orf131; Cone Dystrophy 3; Prev. GUCA1; DJ139D8.6; Prev. GUCA; Guanylate Cyclase-Activating Protein, Photoreceptor 1; GCAP1; Guanylate Cyclase Activator 1A (Retina); GCAP; Chromosome 6 Open Reading Frame 131; Guanylyl Cyclase-Activa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-D3419
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
