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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
spin
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "spin" in MCE Product Catalog:
Cat. No.: HY-W271506
CAS No.: 10135-38-3
Synonyms: 3,3,5,5-Tetramethyl-1-pyrroline 1-oxide
Research Areas:
TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes .
Cat. No.: HY-W002004S
CAS No.: 97461-87-5
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17,15N
Cat. No.: HY-121511
CAS No.: 2101206-36-2
Target:
Research Areas:
EML631 is a SPIN1 inhibitor with a Kd of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research .
Cat. No.: HY-P701841
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: spin4; FLJ44984; spindlin Family Member 4; spindlin Family, Member 4; TDRD28; LJBS; spindlin-4
Species:
Human
Source:
E. coli
Cat. No.: HY-P701840
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: spin4; FLJ44984; spindlin Family Member 4; spindlin Family, Member 4; TDRD28; LJBS; spindlin-4
Species:
Human
Source:
E. coli
Cat. No.: HY-N15769
CAS No.: 1585969-98-7
Category:
Target:
Cat. No.: HY-179762
CAS No.: 63658-52-6
16:0 Tempo PC is a phosphocholine with a TEMPO group. (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) is commonly used as a spin-label for lipid membrane studies. TEMPO alwayss acts as a spin probe are in electron resonance spectroscopy, as a paramagnetic contrast agent in NMR, and as oxygen-sensitive probes in biological systems.
Cat. No.: HY-179880
CAS No.: 107576-70-5
16:0-18:1 Tempo PC is a phosphocholine with a TEMPO group. (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) is commonly used as a spin-label for lipid membrane studies. TEMPO alwayss acts as a spin probe are in electron resonance spectroscopy, as a paramagnetic contrast agent in NMR, and as oxygen-sensitive probes in biological systems.
Cat. No.: HY-P83523
Synonyms: GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; spin; Williams-Beuren syndrome chromosomal region
Cat. No.: HY-P83523A
Synonyms: GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; spin; Williams-Beuren syndrome chromosomal region
Cat. No.: HY-P77099
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NCKIPSD; Diaphanous Protein Interacting Protein; NCK Interacting Protein With SH3 Domain; 54 KDa Vimentin-Interacting Protein; AF3P21; WASP-Interacting SH3-Domain Protein; spin90; 54 KDa VacA-Interacting Protein; WISH; SH3 Adapter Protein spin90; WASLBP;
Species:
Human
Source:
E. coli
Cat. No.: HY-131801
CAS No.: 58045-00-4
Target:
Research Areas:
3'NH2-GDP can be used to synthesize spin-labelled nucleotides. 3'NH2-GDP has Kd values of 12 nM in complex formation with EF-Tu from E. coli .
Cat. No.: HY-179316
CAS No.: 22690-04-6
Target:
Research Areas:
4-Phosphonooxy-tempo is an anionic nitroxide spin probe. 4-Phosphonooxy-tempo can be transported by a band 3 protein to permeate the membrane and then react with reductants contained in cytosol. 4-Phosphonooxy-tempo can be used as biomembrane anion channel functional probe .
Cat. No.: HY-180497
CAS No.: 83016-63-1
Target:
Research Areas:
DBNBS is a radical scavenger. DBNBS undergoes non-radical nucleophilic addition to bind directly to cysteine (e.g., Cys-34 of BSA) to form a hydroxylamine, which is subsequently oxidized to produce an artifact spin adduct signal. DBNBS can be used for detecting biological free radicals .
Cat. No.: HY-117925
CAS No.: 1529779-90-5
Personalised postprandial-targeting is a way to modulate water-heme interactions with activity against low-spin P450 complexes. Personalised postprandial-targeting is able to maintain the axial water ligands of CYP2C9 even in the presence of inhibitors. Personalised postprandial-targeting also allows the hydrogen atoms of the axial water ligands to be observed by EPR spectroscopy, providing insights into the enzyme active site .
Cat. No.: HY-118558
CAS No.: 51308-54-4
Synonyms: S-1358
Research Areas:
Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops .
Cat. No.: HY-K3125
MCE Extracellular Vesicle (EV) Ultrafiltration Concentrator (500 μL, 100 kDa) features a polyethersulfone (PES) ultrafiltration membrane with a molecular weight cutoff (MWCO) of 100 kDa. It provides rapid filtration, high concentration efficiency, and high exosome recovery. Its specialized anti-dry-spin design effectively minimizes sample loss caused by excessive centrifugation and membrane drying, thereby helping maintain high exosome recovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
