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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
82 Results for "
HAT
" in MedChemExpress (MCE) Product Catalog:
Products (82)
82 Results for "HAT" in MCE Product Catalog:
Cat. No.: HY-183422
CAS No.: 2379416-16-5
Target:
Research Areas:
HAT-IN-11 is a Histone acetyltransferase (HAT) inhibitor. HAT-IN-11 is used for research on lymphoma and castration-resistant prostate cancer .
Cat. No.: HY-175979
HAT-IN-9 (Compound 3F) is a selective proliferation inhibitor targeting Trypanosoma brucei. HAT-IN-9 inhibits the proliferation and division of Trypanosoma brucei. HAT-IN-9 is promising for research of African trypanosomiasis (HAT, i.e., sleeping sickness) .
Cat. No.: HY-RS17140
Target:
Research Areas:
Hat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76680
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TMPRSS11D; Adrenal Secretory Serine Protease; Transmembrane Serine Protease 11D; Transmembrane Protease Serine 11D; HAT; Airway Trypsin-Like Protease; ASP; Airway Trypsin Like Protease; Transmembrane Protease, Serine 11D
Species:
Human
Source:
HEK293
Cat. No.: HY-K3016
MCE HAT Supplement (50×) can be added to cell culture medium as a selection agent for post-fusion selection of HGPRT-myeloma hybridoma cells used for antibody production. The 10 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
Cat. No.: HY-N9859
CAS No.: 1068661-35-7
Category:
Simple Phenylpropanols Cynanchum amplexicaule (Sieb. et Zucc.) Hemsl. Phenylpropanoids Plants Apocynaceae Extract
Target:
Cat. No.: HY-125188
CAS No.: 2306305-57-5
Target:
Research Areas:
NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
Cat. No.: HY-107455R
CAS No.: 1889279-16-6
Research Areas:
A-485 (Standard) is the analytical standard of A-485 (HY-107455). This product is intended for research and analytical applications. A-485, a chemical probe, is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively .
Cat. No.: HY-W013274S
Research Areas:
CPTH2-d4 is the deuterated-labeled CPTH2 (HY-W013274). CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) .
Cat. No.: HY-181669
CAS No.: 3034595-62-2
Target:
Research Areas:
P300-IN-6 is an orally active histone acetyltransferase p300 HAT domain inhibitor with human IC50 values of 7 nM. P300-IN-6 suppresses c-Myc expression, decreases H3K18ac and H3K27ac levels, and inhibits cancer cell proliferation.P300-IN-6 suppresses tumor growth in xenograft mouse models.P300-IN-6 can be used for the research of multiple myeloma .
Cat. No.: HY-189650
Research Areas:
AMPAR/Nav1.2-IN-1 is a blood-brain barrier-penetrant AMPAR inhibitor and Nav1.2 blocker with IC50 values of 12.7 and 7.01 μM, respectively. AMPAR/Nav1.2-IN-1 inhibits AMPA-mediated excitatory currents and neuronal Nav1.2 voltage-gated sodium channels. AMPAR/Nav1.2-IN-1 scavenges free radicals via HAT and SET, increases GSH and SOD while decreasing MDA, and restores GABA-glutamate homeostasis by attenuating glutamate elevation and increasing GABA. AMPAR/Nav1.2-IN-1 can be used for epilepsy research .
Cat. No.: HY-P702892
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: EP300; Histone Crotonyltransferase P300; EP300 Lysine Acetyltransferase; Histone Butyryltransferase P300; P300; Protein Lactyltransferas P300; Histone Acetyltransferase P300; E1A-Associated Protein P300; E1A Binding Protein P300; P300 HAT; KAT3B; E1A-Bind
Species:
Human
Source:
E. coli
Cat. No.: HY-114510
CAS No.: 1020399-52-3
PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia .
Cat. No.: HY-P702963
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EP300; Histone Crotonyltransferase P300; EP300 Lysine Acetyltransferase; Histone Butyryltransferase P300; P300; Protein Lactyltransferas P300; Histone Acetyltransferase P300; E1A-Associated Protein P300; E1A Binding Protein P300; P300 HAT; KAT3B; E1A-Bind
Species:
Mouse
Source:
E. coli
Cat. No.: HY-L005M
295 compounds
Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer.
MCE provide a unique collection of 295 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
