AMPAR/Nav1.2-IN-1

AMPAR/Nav1.2-IN-1 (compound 6A) (50 μM) produces the strongest inhibitory effect on AMPAR- and VGSC-mediated currents in isolated hippocampal CA1 pyramidal neurons^[1].
AMPAR/Nav1.2-IN-1 (30 μM) blocks Nav1.2 in HEK293 cells with an IC₅₀ of 7.01 μM^[1].
AMPAR/Nav1.2-IN-1 inhibits AMPAR with an IC₅₀ of 12.7 μM and has lower potency against NMDAR^[1].
AMPAR/Nav1.2-IN-1 exhibits high blood-brain barrier permeability in the PAMPA-BBB assay, with a Pe of 18.70 × 10^-6 cm/s^[1].
AMPAR/Nav1.2-IN-1 shows minimal inhibition of CYP3A4, CYP2D6, and CYP2C9 (inhibition rates of 2.12%, 3.11%, and 4.07%, respectively)^[1].
AMPAR/Nav1.2-IN-1 (200 μM) maintains >75% viability in PC12 and HEK293T cells^[1].
AMPAR/Nav1.2-IN-1 inhibits cardiac NaV1.5 current by less than 10%^[1].
AMPAR/Nav1.2-IN-1 shows antioxidant activity in DPPH, ABTS, and FRAP assays, with an ABTS IC₅₀ of 34.46 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .