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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
535 Results for "
LC
" in MedChemExpress (MCE) Product Catalog:
Products (535)
535 Results for "LC" in MCE Product Catalog:
Cat. No.: HY-168892
CAS No.: 380636-64-6
LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity .
Cat. No.: HY-174412
CAS No.: 2027514-32-3
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LC-PDin06 is a selective PRDX1 inhibitor with an IC50 of 0.042 μM. LC-PDin06, a Celastrol (HY-13067) derivative, shows potent antiproliferative activity against colorectal cancer cells by significantly increasing ROS levels .
Cat. No.: HY-174981
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LC-MF-4 is an orally active VHL-recruiting FGFR3 PROTAC degrader and hERG potassium channel inhibitor. LC-MF-4 has an IC50 of 16.6 nM against human FGFR3, exhibits inhibitory activity against hERG potassium channels, suppresses the expression of genes related to mitochondrial biogenesis and ATP synthesis, inhibits cancer cell proliferation, and shows significant antitumor activity in mice. LC-MF-4 can be used in the research of bladder cancer, urothelial carcinoma, FGFR3 Y373C mutant cancers, and FGFR3-TACC3 fusion-positive cancers .
Cat. No.: HY-172018
CAS No.: 3040858-60-1
CP-LC-0729 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
Cat. No.: HY-126497
CAS No.: 1252257-56-9
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LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
Cat. No.: HY-14892B
CAS No.: 1375415-82-9
Synonyms: LC15-0444 tartrate hydrate
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Gemigliptin (LC15-0444 ) tartrate hydrate is a selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate hydrate exhibits potent anti-glycation properties. Gemigliptin tartrate hydrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Cat. No.: HY-139403
CAS No.: 2561529-98-2
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MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM) .
Cat. No.: HY-P4135
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Cat. No.: HY-169347
CAS No.: 3085297-83-9
Synonyms: LC-05-004
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dCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes. .
Cat. No.: HY-145890
CAS No.: 2495750-20-2
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LC kinetic stabilizer-2 is a potent amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC50 of 24 nM .
Cat. No.: HY-168891
CAS No.: 1281081-32-0
LC3B recruiter 1 (compound 33R) is an LC3B recruiter fragment. LC3B recruiter 1 directly interacts with LC3B with a KD value of 2.87 µM .
Cat. No.: HY-171113
CAS No.: 3112948-10-1
Synonyms: VC-LC-1074
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).
Cat. No.: HY-162538
CAS No.: 3053823-69-8
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LC-MI-3 is an orally active IRAK4 PROTAC degrader with an IC50 of 57.2 nM and high selectivity among human protein kinases. LC-MI-3 eliminates IRAK4 kinase and scaffolding functions via the cereblon E3 ubiquitin ligase and ubiquitin-proteasome systems. LC-MI-3 inhibits downstream nuclear factor-κB and IRAK4-mediated inflammatory signaling pathways. LC-MI-3 can be used for the research of acute lung injury, sepsis, psoriasis, and inflammatory diseases .
Cat. No.: HY-W590537
Cat. No.: HY-145889
CAS No.: 2495750-19-9
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LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
Cat. No.: HY-172014
CAS No.: 3040858-73-6
CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
Cat. No.: HY-172015
CAS No.: 3040859-45-5
CP-LC-1143 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
