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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
535 Results for "
LC
" in MedChemExpress (MCE) Product Catalog:
Products (535)
535 Results for "LC" in MCE Product Catalog:
Cat. No.: HY-P4125A
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LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity .
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Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-14892
CAS No.: 911637-19-9
Synonyms: LC15-0444
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Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes .
Synonyms: LC350189
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Tigulixostat (LC350189) is an orally active non-purine selective xanthine oxidase inhibitor. Tigulixostat has IC50 values of 0.003 µM and 0.073 µM in bovine milk and rat plasma, respectively. Tigulixostat can effectively reduce serum uric acid levels and can be used in the research of gout and hyperuricemia .
MRTX849 acid, a derivative of MRTX849, can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM) .
Cat. No.: HY-P4125
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Cat. No.: HY-177888
CAS No.: 111142-68-8
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Lc2Cer(d18:1, 22:0) is a lactosylceramide containing d18:1, C22:0 ceramides. Lc2Cer(d18:1, 22:0) can be used for renal cortical epithelial cell research .
Cat. No.: HY-RS08029
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MAP1LC3B Human Pre-designed siRNA Set A contains three designed siRNAs for MAP1LC3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175665
CAS No.: 2839637-57-7
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LC3 liagnd-2 is an E3 ligase ligand. LC3 liagnd-2 can be used for synthesis of PROTAC PDEδ autophagic degrader 1 (HY-157458) .
Cat. No.: HY-126495
CAS No.: 150244-18-1
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Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
Cat. No.: HY-D0799A
CAS No.: 190598-57-3
Cat. No.: HY-W123007
CAS No.: 125559-00-4
Synonyms: Succinimidyl-[4-(N-maleimidomethyl)]-cyclohexane-1-carboxy-(6-amidocaproate)
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LC-SMCC (Succinimidyl-[4-(N-maleimidomethyl)]-cyclohexane-1-carboxy-(6-amidocaproate)) is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-14892C
CAS No.: 1523530-62-2
Synonyms: LC15-0444 hydrochloride
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Gemigliptin hydrochloride is the hydrochloride salt of Gemigliptin (HY-14892). Gemigliptin hydrochloride is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin hydrochloride exhibits potent anti-glycation properties. Gemigliptin hydrochloride can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Cat. No.: HY-137516A
CAS No.: 2502156-12-7
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .
Cat. No.: HY-158062
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LC-1-40 is a selective NUDT1 PROTAC degrader with a DC50 of 0.97 nM. LC-1-40 recruits NUDT1 to the CRBN E3 ubiquitin ligase complex and mediates its degradation via a proteasome-dependent pathway. LC-1-40 induces increased nucleotide damage and Apoptosis in tumors. LC-1-40 can be used in studies related to Mycn-amplified neuroblastoma .
Cat. No.: HY-172916
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR (IC50 values are 71.6 and 8.9 nM, respectively). LC-SF-14 inhibits FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation. LC-SF-14 inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). LC-SF-14 has antitumor activity in the SNU-16 xenograft mouse model. LC-SF-14 can be used in FGFR2-driven gastric cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
