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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
84 Results for "
Vancomycin-
" in MedChemExpress (MCE) Product Catalog:
Products (84)
84 Results for "Vancomycin-" in MCE Product Catalog:
Cat. No.: HY-162775
CAS No.: 50566-97-7
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TST1N-224 is a potent response regulator VraRC inhibitor. TST1N-224 can disrupt VraRC-DNA complex formation (IC50=60.2 μM). TST1N-224 exhibits interference with VraRC binding to its cognate DNA through a fast-on-fast-off binding mechanism (KD=23.4 μM). TST1N-224 predominantly interacts with the α9- and α10-helixes of the DNA-binding domain of VraR. TST1N-224 inhibits the growths of S. aureus (SA; MIC>126 μM), Methicillin-resistant S. aureus (MRSA; MIC>126 μM), and Vancomycin-intermediate S. aureus (VISA; MIC=63 μM). TST1N-224, an antimicrobial agent, evidently enhances the susceptibility of VISA to both Vancomycin (HY-B0671) and Methicillin (HY-B0974) .
Cat. No.: HY-161935
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Cat. No.: HY-B1831AR
CAS No.: 192564-14-0
Synonyms: LY333328 diphosphate (Standard)
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Oritavancin (diphosphate) (Standard) is the analytical standard of Oritavancin (diphosphate). Oritavancin diphosphate (Standard), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide antibiotic with bactericidal activity against gram-positive organisms. Oritavancin diphosphate (Standard) shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate (Standard) inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate (Standard) inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate (Standard) enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity .
Cat. No.: HY-12770R
CAS No.: 14367-47-6
Synonyms: Mebeverine metabolite Mebeverine alcohol (Standard)
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Mebeverine alcohol (Standard) is an analytical standard for Mebeverine alcohol. This product is intended for research and analytical applications. Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of Chloramphenicol (HY-B0239) and Lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .
Cat. No.: HY-137527
CAS No.: 24570-39-6
Cat. No.: HY-N19136
CAS No.: 163768-83-0
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Cat. No.: HY-E71646
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3,5-Dihydroxyphenylacetyl-CoA synthase (EC 2.3.1.246), characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin.
Cat. No.: HY-E71066
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(3R,6E)-Nerolidol synthase (EC 1.13.11.80) , characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5-dihydroxyphenyl) glycine, a component of the glycopeptide antibiotic vancomycin.
Cat. No.: HY-N14172
CAS No.: 69176-72-3
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Cat. No.: HY-184679
CAS No.: 890179-59-6
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MCZ-038 is a thiourea antibiotic with bactericidal activity. MCZ-038 exerts its effects by interfering with the lipid organization or fluidity of bacterial cell membranes . MCZ-038 can be used in studies related to drug-resistant Staphylococcus aureus infections and Vancomycin (HY-B0671)-resistant Enterococcus faecium infections .
Cat. No.: HY-188005
CAS No.: 112921-07-0
D-Ala-AMS is an enzyme inhibitor with activity against cysteine adenylation domains and D-alanine adenylation enzymes. D-Ala-AMS mimics the cognate D-alanyl-AMP reaction intermediate and blocks the adenylation activity of its targets. D-Ala-AMS blocks the recovery of bacterial growth in the presence of Vancomycin. D-Ala-AMS can be used in studies related to Gram-positive bacterial infections .
Cat. No.: HY-182823
CAS No.: 155386-25-7
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N-Nitrosovancomycin is an antibacterial agent and an N-terminal nitrosated derivative of vancomycin. N-Nitrosovancomycin exhibits antibacterial activity against Gram-positive bacteria in vitro, but shows no activity against Gram-negative E. coli. The modified N-terminal amino group of N-Nitrosovancomycin cannot be protonated, yet the compound still retains in vitro antibacterial activity. N-Nitrosovancomycin can be used in studies related to Gram-positive bacterial infections .
Cat. No.: HY-N19214
CAS No.: 3040055-91-9
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Cat. No.: HY-N15435A
Conimine TFA is a steroidal alkaloid, antibacterial agent and potentiator. Conimine TFA is isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Conimine TFA exhibits intrinsic antibacterial activity against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. When combined with Penicillin, Conimine TFA shows synergistic antibacterial effects against methicillin-resistant Staphylococcus aureus; when combined with Vancomycin (HY-B0671), it exerts synergistic antibacterial effects against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus .
Cat. No.: HY-N19135
CAS No.: 163768-82-9
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Cat. No.: HY-182798
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Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections .
Cat. No.: HY-N21929
CAS No.: 136660-70-3
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Cat. No.: HY-P11085A
Cat. No.: HY-69174
CAS No.: 228862-97-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
