Conimine TFA
Conimine TFA is a steroidal alkaloid, antibacterial agent and potentiator. Conimine TFA is isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Conimine TFA exhibits intrinsic antibacterial activity against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. When combined with Penicillin, Conimine TFA shows synergistic antibacterial effects against methicillin-resistant Staphylococcus aureus; when combined with Vancomycin (HY-B0671), it exerts synergistic antibacterial effects against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
For research use only. We do not sell to patients.
- Formula: C24H37F3N2O2
- Molecular Weight:442.56
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Storage:
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Conimine (two-fold serial dilutions; 24 h) TFA inhibits the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 128 μg·mL−1 for both strains[1].
Conimine (1/64-1 of its MIC (128 μg·mL-1)) TFA exhibits synergistic antibacterial activity with penicillin against methicillin-resistant Staphylococcus aureus (MRSA) and with vancomycin against both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), while showing a nonrelative effect with penicillin against MSSA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 442.56
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Formula C24H37F3N2O2
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Color White to off-white
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SMILES
C[C@H]1[C@]2([H])[C@]3(CN1)[C@](CC2)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)NC)=CC4)C)([H])CC3.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under argon
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Conimine TFA Related Classifications
HY-N15435A Related Classifications
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