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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
cold-induced depolymerization
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "cold-induced depolymerization" in MCE Product Catalog:
Cat. No.: HY-N0060AR
CAS No.: 24276-84-4
Synonyms: Coniferic acid sodium (Standard)
Cat. No.: HY-W002112R
CAS No.: 5746-86-1
Synonyms: Nornicotine (Standard)
Cat. No.: HY-W002112S1
Synonyms: Nornicotine-d7
Cat. No.: HY-W854934
CAS No.: 114231-14-0
Target:
Research Areas:
IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM). IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma .
Cat. No.: HY-P86650
Synonyms: C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1
Cat. No.: HY-P80766A
Synonyms: C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1
Cat. No.: HY-P810728
Synonyms: C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1
Cat. No.: HY-P80766AA
Synonyms: C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1
Cat. No.: HY-P79001
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRLF1; CLF; Cytokine Receptor Like Factor 1; Cytokine Type 1 Receptor CRLP-1; CLF-1; cold-induced Sweating Syndrome; Cytokine Receptor-Like Factor 1; Class I Cytokine Receptor; Cytokine-Like Factor 1; Zcytor5; CISS1; ZcytoR5; CISS; NR6
Species:
Mouse
Source:
HEK293
Cat. No.: HY-110181R
CAS No.: 883976-12-3
Target:
Research Areas:
M8-B (Standard) is the analytical standard of M8-B (HY-110181). This product is intended for research and analytical applications. M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .
Cat. No.: HY-182478
CAS No.: 124711-23-5
Target:
Research Areas:
MDL-27048, a tubulin inhibitor, binds competitively, reversibly to the Colchicine (HY-16569)-binding site on tubulin heterodimers. MDL-27048 inhibits microtubule assembly, induces slow depolymerization of preassembled microtubules, disrupts microtubule polymerization-depolymerization dynamics, and disrupts cytoplasmic microtubule networks. MDL-27048 exerts growth inhibitory effects on human cancer cells, induces mitotic arrest, and does not disrupt actin filaments at microtubule-depolymerizing concentrations. MDL-27048 can be used for the research of malignant tumors .
Cat. No.: HY-P706014
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CEMIP; HYBID; KIAA1199; Cell migration-inducing and hyaluronan-binding protein; EC 3.2.1.35; Hyaluronan binding protein involved in hyaluronan depolymerization
Species:
Human
Source:
E. coli
Cat. No.: HY-N16438
CAS No.: 64925-81-1
Category:
Target:
Cat. No.: HY-E71677
Target:
Research Areas:
3-Deoxy-2-octulosonidase (EC 3.2.1.124) from a bacteriophage catalyses the depolymerization of capsular polysaccharides containing 3-deoxy-2-octulosonide in the cell wall of Escherichia coli.
Cat. No.: HY-181428
CAS No.: 3061439-13-9
Target:
Research Areas:
Fmoc-Gly-Gly-Phe-Gly-Docetaxel (compound 16h-3) is a drug-linker conjugate for ADC, which comprises a microtubule depolymerization inhibitor and a linker. Puxitatug samrotecan drug-linker can be used to synthesize antibody-drug conjugate (ADC) .
Cat. No.: HY-180347
CAS No.: 1204408-27-4
Target:
Research Areas:
HD-800 is a tubulin inhibitor with an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. HD-800 can be used to generate a radioactive tracer [11C]HD-800, and [11C]HD-800 can penetrate the blood-brain barrier and be used for positron emission tomography (PET) in various neurological diseases .
Cat. No.: HY-179516
CAS No.: 3087064-94-3
Target:
Research Areas:
AKT1-IN-11, a Podophyllotoxin (HY-15552) derivative, is a AKT1/tubulin dual inhibitor. AKT1-IN-11 down-regulates the phosphorylation level of AKT kinase in tumor cells, disrupting cell proliferation, causeing G2/M phase arrest and inducing apoptosis. AKT1-IN-11 also promotes tubulin depolymerization. AKT1-IN-11 can be used for the research of colorectal cancer .
Cat. No.: HY-177898
CAS No.: 1620225-37-7
DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer .
Cat. No.: HY-16457
CAS No.: 791635-59-1
Synonyms: MST 997
Target:
Research Areas:
Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
