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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
192 Results for "
P2Y Receptor
" in MedChemExpress (MCE) Product Catalog:
Products (192)
192 Results for "P2Y Receptor" in MCE Product Catalog:
Cat. No.: HY-113273C
CAS No.: 94108-02-8
Synonyms: Ap5A pentalithium; P1,P5-Di(adenosine-5'-)pentaphosphate pentalithium
Target:
Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) pentalithium is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain) .
Cat. No.: HY-P705683
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SUCNR1; G Protein-Coupled Receptor 91; Prev. GPR91; P2Y Purinoceptor 1; G-Protein Coupled Receptor 91; Succinate Receptor 1; P2Y Purinoceptor 1-Like
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-103055
CAS No.: 1160271-31-7
Target:
Research Areas:
PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .
Cat. No.: HY-P701629
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: P2RY1; P2Y Purinoceptor 1; Purinergic Receptor P2Y1; ADP Receptor; P2Y1; P2 Purinoceptor Subtype Y1; SARCC; Platelet ADP Receptor; Suppressing Androgen Receptor In Renal Cell Carcinoma; Purinergic Receptor; Purinergic Receptor P2Y, G-Protein Coupled, 1; A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-13104R
CAS No.: 711019-86-2
Target:
Research Areas:
MRS 2578 (Standard) is the analytical standard of MRS 2578. This product is intended for research and analytical applications. MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .
Cat. No.: HY-137607A
Target:
Research Areas:
UMP-CP trisodium (Compound 3), a nucleotide, is a P2Y14 receptor agonist with an EC50 of 160 nM for P2Y14 receptor over the P2Y6 receptor. UDP trisodium can be used for pain, diabetes, cystic fibrosis and other pulmonary diseases research .
Cat. No.: HY-123202
CAS No.: 860623-35-4
Target:
Research Areas:
MRS2603 is a pyridoxal derivative. MRS2603 antagonized both P2Y1 and P2Y13 receptors .
Cat. No.: HY-122211
CAS No.: 1047980-53-9
Target:
Research Areas:
MRS2802 is a P2Y14 receptor agonist with an EC50 value of 63 nM. MRS2802 can effectively activate the P2Y14 receptor and may play a role in regulating platelet function. The selectivity and activity of MRS2802 are conducive to in-depth research on the biological functions and pharmacological properties of P2Y receptors. The development of MRS2802 provides a potential inhibitory strategy for the search for new antiplatelet compounds .
Cat. No.: HY-174126
Target:
Research Areas:
P2Y1 antagonist 2 (Compound 19) is a P2Y1 receptor antagonist (IC50: 0.49 μM). P2Y1 antagonist 2 has significant antiplatelet aggregation activity and exerts its effects by inhibiting P2Y1 receptor. P2Y1 antagonist 2 can upregulate nuclear Nrf2 protein levels, exhibit neuroprotective effects, and resist oxidative stress damage. P2Y1 antagonist 2 can effectively reduce cerebral infarction area and improve neurobehavioral function, and can be used in the study of ischemic stroke .
Target:
Research Areas:
P2Y12 antagonist 1 (compound 26) is a P2Y12 receptor antagonist with a Ki of 3.13 μM. P2Y12 antagonist 1 can be used to inhibit platelet aggregation and is a potential antithrombotic agent .
Cat. No.: HY-P701630
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: P2RY1; P2Y Purinoceptor 1; Purinergic Receptor P2Y1; ADP Receptor; P2Y1; P2 Purinoceptor Subtype Y1; SARCC; Platelet ADP Receptor; Suppressing Androgen Receptor In Renal Cell Carcinoma; Purinergic Receptor; Purinergic Receptor P2Y, G-Protein Coupled, 1; A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-110092A
Purity: ≥95.0%
Target:
Research Areas:
PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors .
Cat. No.: HY-174153
CAS No.: 1404529-43-6
Target:
Research Areas:
PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y12 receptors (KD=4.57 nM). PSB-22219 is promising for research of P2Y12 receptor-associated neuroinflammation .
Cat. No.: HY-137612C
Synonyms: Rp-Uridine 5'-O-1-thiotriphosphate tetrasodium
Target:
Research Areas:
Rp-UTP-α-S (Rp-Uridine 5'-O-(1-thiotriphosphate)) tetrasodium is a nucleotide agonist of purinergic P2Y2 and P2Y4 receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y2 or P2Y4 expressing 1321N1 cells with EC50 values of 5.4 and 27 μM .
Cat. No.: HY-134353
CAS No.: 35094-45-2
Synonyms: Adenosine 5'-(β-thiodiphosphate)
Target:
Research Areas:
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S can be used in the research of diseases such as inflammation and diabetes .
Cat. No.: HY-137606
CAS No.: 10527-48-7
Synonyms: UP4A
Target:
Research Areas:
Uridine adenosine tetraphosphate (UP4A) is an endothelium-derived vasoconstrictor that primarily acts through the P2X1 receptor and possibly through the P2Y2 and P2Y4 receptors. Uridine adenosine tetraphosphate can be used in the study of cardiovascular diseases .
Cat. No.: HY-108651
CAS No.: 1266569-94-1
Synonyms: UTPγS trisodium
Target:
Research Areas:
Uridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability .
Cat. No.: HY-137612
CAS No.: 71214-29-4
Synonyms: Uridine 5'-O-1-thiotriphosphate
Target:
Research Areas:
Sp-UTP-α-S (Uridine 5-0-1-thiotrirhosphate) is a P2Y2 and P2Y4 receptor activator. Sp-UTP-α-S can be used in cancer research .
Cat. No.: HY-137616C
Target:
Research Areas:
Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y2 receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y2-expressing 1321N1 cells with an EC50 of 12.5 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
