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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
96 Results for "
Smo
" in MedChemExpress (MCE) Product Catalog:
Products (96)
96 Results for "Smo" in MCE Product Catalog:
Cat. No.: HY-N0247R
CAS No.: 58558-08-0
Category:
Umbelliferae Extract Plants Saccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Monosaccharides
Target:
Cat. No.: HY-183335
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC50 of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma .
Cat. No.: HY-108508R
CAS No.: 1177600-74-6
Target:
Research Areas:
SMANT hydrochloride (Standard) is the analytical standard of SMANT (hydrochloride) (HY-108508). This product is intended for research and analytical applications. SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo .
Cat. No.: HY-P703220
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Smo; Seven Transmembrane Helix Receptor; Prev. SmoH; Smoothened (Drosophila) Homolog; FZD11; Smoothened Homolog (Drosophila); Smoothened, Seven Transmembrane Spanning Receptor; Smoothened Homolog; Smoothened, Frizzled Family Receptor; CRJS; Frizzled Famil
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704888
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: Smo; Seven Transmembrane Helix Receptor; Prev. SmoH; Smoothened (Drosophila) Homolog; FZD11; Smoothened Homolog (Drosophila); Smoothened, Seven Transmembrane Spanning Receptor; Smoothened Homolog; Smoothened, Frizzled Family Receptor; CRJS; Frizzled Famil
Species:
Human
Source:
HEK293
Cat. No.: HY-108507R
CAS No.: 330829-30-6
Target:
Research Areas:
MRT-10 (Standard) is the analytical standard of MRT-10 (HY-108507). This product is intended for research and analytical applications. MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .
Cat. No.: HY-15108R
CAS No.: 483367-10-8
Target:
Research Areas:
Purmorphamine (Standard) is the analytical standard of Purmorphamine (HY-15108). This product is intended for research and analytical applications. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
Cat. No.: HY-110240R
CAS No.: 548779-60-8
Target:
Research Areas:
IHR-1 (Standard) is the analytical standard of IHR-1 (HY-110240). This product is intended for research and analytical applications. IHR-1 is a cell membrane impermeable Smo antagonist .
Cat. No.: HY-100224R
CAS No.: 304909-07-7
Target:
Research Areas:
SANT-1 (Standard) is the analytical standard of SANT-1 (HY-100224). This product is intended for research and analytical applications. SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .
Cat. No.: HY-W700539
CAS No.: 141998-21-2
Target:
Research Areas:
N1-Acetyl triethylenetetramine is a polyamine derivative with a free amino terminus. N1-Acetyl triethylenetetramine serves as a substrate for spermidine/spermine N1-acetyltransferase (SSAT) and exerts competitive inhibitory effects on APAO and SMO. N1-Acetyl triethylenetetramine can be catalyzed to undergo acetylation by recombinant mouse SSAT. It is applicable in metabolism-related research .
Cat. No.: HY-100036R
CAS No.: 935273-79-3
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Research Areas:
MK-4101 (Standard) is the analytical standard of MK-4101 (HY-100036). This product is intended for research and analytical applications. MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis .
Cat. No.: HY-W338819
CAS No.: 25122-41-2
Target:
Research Areas:
Clobetasol is a glucocorticoid and Smoothened agonist that can cross the blood-brain barrier. Clobetasol induces Smo-dependent activation of the Shh signaling pathway and nuclear translocation of Gli1. Clobetasol promotes remyelination and reduces myelin loss in lesions of neuromyelitis optica (NMO). Clobetasol may cause adrenal suppression, cushingoid appearance, and local adverse reactions including dysgeusia, xerostomia, and gastroesophageal burning. Clobetasol can be used in research related to neurodegenerative diseases, oral lichen planus, mucous membrane pemphigoid, and neuromyelitis optica .
Cat. No.: HY-L020
654 compounds
The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.
MCE designs a unique collection of 654 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.
Cat. No.: HY-184378
CAS No.: 2922221-22-3
Target:
Research Areas:
MDB5 is a Hedgehog pathway and Smoothened inhibitor that binds to the 7-TM domain of Smo . MDB5 reduces hepatic stellate cell activation, extracellular matrix-related gene expression, collagen deposition, hydroxyproline content and epithelial-mesenchymal transition, and prevents sinusoidal endothelial cell capillarization . MDB5 induces G1 and S phase cell cycle arrest, triggers apoptosis by upregulating Bax and downregulating Bcl-2, and also decreases oxygen consumption rate, glucose uptake, transglutaminase activity and fibronectin matrix assembly . MDB5 reduces the levels of liver injury markers, hepatic triglyceride deposition and hepatic steatosis, restores the tissue structure of the kidney and spleen, and inhibits pancreatic tumor growth without causing body weight loss . MDB5 can be loaded into PEG-PCC-g-DC micelles, achieving high drug loading, sustained release, improved water solubility, enhanced cellular uptake and optimized hepatic distribution, with good tolerance in mice . MDB5 is applicable to research related to alcohol-associated liver disease, liver fibrosis and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
