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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
UGT
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "UGT" in MCE Product Catalog:
Cat. No.: HY-E72116
Target:
Research Areas:
Human UGT2B4 is a UDP-glucuronosyltransferase. UGT2B4 catalyzes the glucuronidation of bile acids, Carvedilol (HY-B0006) and 6-hydroxylated bile acids to form glucuronide derivatives. UGT2B4 participates in the inactivation of endogenous and exogenous substances, including catechol estrogens, C19 steroids, phenols and monoterpenoids. Human UGT2B4 can be used in the research of hypertension, angina pectoris, chronic heart failure and intrahepatic cholestasis .
Cat. No.: HY-E72111
Human UGT1A9 is a UDP-glucuronosyltransferase. UGT1A9 catalyzes the transfer of glucuronic acid from UDP-glucuronic acid (HY-N7033) to Umbelliferone (HY-N0573), 4-methylumbelliferone (HY-N0187), Scopoletin (HY-N0342), and α-Naphthol. Functional folding of UGT1A9 requires N-glycosylation; the deglycosylated mature protein still retains full activity .
Cat. No.: HY-RS19083
Target:
Research Areas:
Ugt1a8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21974
Target:
Research Areas:
Ugt1a4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23238
Target:
Research Areas:
Ugt1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26323
Target:
Research Areas:
Ugt1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26709
Target:
Research Areas:
Ugt2b7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ugt2b7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702034
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC35A2; UGT2; Prev. UGALT; Solute Carrier Family 35 (UDP-Galactose Transporter), Member 2; UDP-Gal-Tr; CDNA FLJ59970, Highly Similar To UDP-Galactose Translocator; UGTL; CDNA FLJ53300, Highly Similar To UDP-Galactose Translocator; UGT; UDP-Galactose Tran
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P811655
Synonyms: GNT1, UGT1, UGT1A1, UDP-glucuronosyltransferase 1A1, Bilirubin-specific UDPGT isozyme 1, UDP-glucuronosyltransferase 1-1, UDP-glucuronosyltransferase 1A isoform 1, hUG-BR1, UDPGT 1-1, UGT1*1, UGT1-01, UGT1.1
Cat. No.: HY-W739842
CAS No.: 17834-04-7
Synonyms: 8-OH Warfarin
Target:
Research Areas:
8-Hydroxywarfarin (8-OH Warfarin) is a CYP2C9 inhibitor. 8-Hydroxywarfarin inactivates the anticoagulant activity of Warfarin (HY-B0687) via 8-hydroxylation. 8-Hydroxywarfarin serves as a glucuronidation substrate for UGT1A1, UGT1A8, UGT1A9, as well as wild-type/mutant UGT1A10. This reaction enhances its polarity, solubility and excretion efficiency, and the process is independent of phenylalanine 90 of UGT1A10. 8-Hydroxywarfarin can be used in studies related to thromboembolic diseases .
Cat. No.: HY-W718401
CAS No.: 1486471-13-9
Synonyms: Belinostat G
Target:
Research Areas:
Belinostat glucuronide (Belinostat G) is the major metabolite formed via UGT1A1-catalyzed O-glucuronidation of Belinostat (HY-10225), and exhibits no activity against cancer cells .
Cat. No.: HY-W777236
CAS No.: 18430-06-3
Category:
Natural Products Plants Selaginella tamariscina (P. Beauv.) Spring Selaginellaceae Extract
Target:
Cat. No.: HY-135541
CAS No.: 365462-24-4
Synonyms: YM150 maleate
Target:
Research Areas:
Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .
Cat. No.: HY-130046R
CAS No.: 547-81-9
Synonyms: 16-epi-Estriol (Standard); 16β,17β-Estriol (Standard)
Research Areas:
16-Epiestriol (Standard) is the analytical standard of 16-Epiestriol (HY-130046). This product is intended for research and analytical applications. 16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
Cat. No.: HY-W701876
CAS No.: 7517-36-4
Target:
Research Areas:
Monocyclohexyl phthalate is a phthalate metabolite and a competitive UGT1A9 inhibitor with an IC50 of 3.29 μM and a Ki of 0.09 μM. Monocyclohexyl phthalate can be used in research on impaired sperm quality and birth weight .
Cat. No.: HY-N19800
CAS No.: 1231899-06-1
Category:
Target:
Cat. No.: HY-P701899
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Probable UDP-glucosyl transferase 73B6; EC:2.4.1.-; UGT73B6
Species:
Others
Source:
E. coli
Cat. No.: HY-P701900
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Probable UDP-glucosyl transferase 73B6; EC:2.4.1.-; UGT73B7
Species:
Others
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
