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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
5-HT4
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "5-HT4" in MCE Product Catalog:
製品番号: HY-14148
CAS 番号: 109872-41-5
Target:
研究分野:
Renzapride hydrochloride is a benzamide that inhibits irritable bowel syndrome and has antagonistic activity at 5-HT(3) receptors and agonistic activity at 5-HT(4) receptors. Renzapride hydrochloride also exhibits antagonistic activity at 5-HT(2B) receptors and has a certain affinity for 5-HT(2A) and 5-HT(2C) receptors .
製品番号: HY-118317
CAS 番号: 90182-92-6
Target:
Zacopride is an orally active 5-HT3 receptor (Ki of 0.38 nM) antagonist and 5-HT4 receptor (Ki of 373 nM) agonist. Zacopride exhibits multiple activities, such as regulating gastrointestinal motility, affecting cardiac function, and exerting anxiolytic and antiemetic effects. Zacopride is currently mainly used in the research of gastrointestinal diseases, cardiovascular diseases, and psychiatric diseases such as anxiety .
製品番号: HY-160921
CAS 番号: 769901-96-4
別名: SL65.0155 free base
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研究分野:
Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models .
製品番号: HY-109065
CAS 番号: 1184662-54-1
別名: DSP-6952 free base
Target:
研究分野:
Minesapride (DSP-6952 free base) is an orally active, selective 5-HT4 receptor partial agonist. Minesapride enhances gastrointestinal motility, colonic transit and defecation function, and inhibits visceral hypersensitivity. Minesapride does not inhibit/induce cytochrome P450 isozymes, has no significant affinity for hERG, and does not trigger the risk of cardiac ischemia via coronary vasoconstriction. Minesapride can be used in research related to constipation-predominant irritable bowel syndrome, chronic constipation, atonic constipation, spastic constipation, functional constipation and functional dyspepsia .
製品番号: HY-RS06475
Target:
研究分野:
Htr4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Htr4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
研究分野:
RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites .
製品番号: HY-10564S
CAS 番号: 2934185-00-7
別名: MCI-9042-d3
製品番号: HY-RS06474
Target:
研究分野:
HTR4 Human Pre-designed siRNA Set A contains three designed siRNAs for HTR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-10564S1
別名: MCI-9042-d4
製品番号: HY-121249
CAS 番号: 191023-43-5
別名: SL65.0155
Target:
研究分野:
Capeserod hydrochloride (SL65.0155) is a 5-HT4(e) receptor partial agonist (Ki=0.6 nM) with potent cognitive enhancing properties. Capeserod hydrochloride acts as a partial agonist in cells expressing 5-HT4(b) and 5-HT4(e) splice variants, stimulating cAMP production with IC50 values of 244 and 29 nM, respectively. Capeserod hydrochloride is used in the study of memory impairment and dementia .
製品番号: HY-168241
CAS 番号: 1639925-34-0
Target:
研究分野:
Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h)5-HT4R). Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT4R (EC50: 23.0 nM). Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay) .
製品番号: HY-184052
CAS 番号: 1809612-31-4
Target:
研究分野:
5-HT4R agonist-3 is a 5-HT4R agonist with an EC50 of 22 nM. 5-HT4R agonist-3 selectively modulates 5-HT4R and induces pro-cognitive activity. 5-HT4R agonist-3 can be used in research related to Alzheimer's disease .
製品番号: HY-120053
CAS 番号: 151898-33-8
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研究分野:
SC-53606 is a potent and selective 5-HT4 receptor antagonist, with a pA2 value of 8.13. SC-53606 acts as an antagonist of 5-HT4 receptor-mediated relaxation of Carbachol (HY-B1208)-induced contractions .
製品番号: HY-106385
CAS 番号: 869493-21-0
別名: VRX-03011 free base
Target:
研究分野:
PRX-03140 is a selective, blood-brain-barrier permeable 5-HT4 receptor agonist with a Ki value of 110 nM against rat brain 5-HT4 receptor. PRX-03140 can increase cortical ACh and histamine levels. PRX-03140 can be used in the research of Alzheimer's disease .
製品番号: HY-106985
CAS 番号: 195627-15-7
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研究分野:
R 116712 is a highly selective and affinity 5-HT4 receptor ligand. R 116712 can prepare isotopic markers .
製品番号: HY-102057R
CAS 番号: 916075-84-8
別名: TD-8954 (Standard)
Target:
研究分野:
Felcisetrag (Standard) is the analytical standard of Felcisetrag (HY-102057). This product is intended for research and analytical applications. Felcisetrag (TD-8954) is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.
製品番号: HY-103108R
CAS 番号: 519148-48-2
Target:
研究分野:
CJ033466 (Standard) is the analytical standard of CJ033466 (HY-103108). This product is intended for research and analytical applications. CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC50 of 9 nM and has gastroprokinetic effect .
製品番号: HY-10457AR
CAS 番号: 866933-51-9
別名: TD-5108 hydrochloride (Standard)
Velusetrag hydrochloride (Standard) is the analytical standard of Velusetrag hydrochloride (HY-10457A). This product is intended for research and analytical applications. Velusetrag (TD-5108) hydrochloride is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag hydrochloride exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag hydrochloride can be used for the research of gastrointestinal diseases and Parkinson's disease .
製品番号: HY-10457R
CAS 番号: 866933-46-2
別名: TD-5108 (Standard)
Velusetrag (Standard) is the analytical standard of Velusetrag (HY-10457). This product is intended for research and analytical applications. Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
