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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
90 Results for "
Complex III
" in MedChemExpress (MCE) Product Catalog:
Products (90)
90 Results for "Complex III" in MCE Product Catalog:
Cat. No.: HY-189426
CAS No.: 3134776-29-4
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Antifungal agent 182 is a mitochondrial complex III (Qo site) inhibitor with an IC50 of 7.05 mg/L. Antifungal agent 182 binds to the Qo pocket, blocking electron transfer and impairing ATP synthesis. Antifungal agent 182 exhibits inhibitory activity against R. solani and P. capsici. Antifungal agent 182 can be used for research on rice sheath blight and Phytophthora capsici infection in pepper .
Cat. No.: HY-W034053
CAS No.: 808142-88-3
Cat. No.: HY-129795
CAS No.: 119433-80-6
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Thiazolylalanine is a synthetic non-protein amino acid containing a thiazole heterocycle. Thiazolylalanine exhibits dual activities of stimulating protein synthesis and inducing protein degradation in rat reticulocytes, but exerts no effects on protein metabolism or the thermolability of phosphoenolpyruvate carboxykinase in hepatoma cells. Thiazolylalanine can serve as the N-terminal component of tripeptide ligands for the synthesis of various organometallic complexes such as gold, mercury, CyRu (II) Cl2, and Cp*Rh (III) Cl2. Thiazolylalanine finds wide application in the research of breast cancer and other related diseases .
Cat. No.: HY-183705
CAS No.: 177776-73-7
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Antimicrobial agent-50 is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC50 of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively .
Cat. No.: HY-189253
CAS No.: 3134062-94-2
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Antimicrobial agent-57 is an agricultural antimicrobial agent that acts as a mitochondrial respiratory chain complex III inhibitor (IC50 = 8.82 mg/L). Antimicrobial agent-57 binds to the Qo site, disrupts the mitochondrial respiratory chain of P. capsici, and inhibits respiration. Antimicrobial agent-57 induces ultrastructural damage to hyphae, including cell wall thickening, mitochondrial degradation, vacuole enlargement, and lipid droplet reduction. Antimicrobial agent-57 inhibits hyphal respiratory metabolism. Antimicrobial agent-57 can be used for research on Phytophthora capsici infection .
Cat. No.: HY-E70989
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D-Fructose Dehydrogenase, Gluconobacter industrius (EC 1.1.99.11) is a heterotrimeric membrane-bound enzyme commonly seen in various Gluconobacter sp. especially in Gluconobacter japonicus (Gluconobacter industrius) .D-Fructose Dehydrogenase consists of subunits I (67kDa), II (51 kDa), and III (20 kDa) and catalyzes the oxidation of D-fructose to produce 5-keto-D-fructose. D-Fructose Dehydrogenase is a flavoprotein-cytochrome c complex with subunits I and II covalently bound to flavin adenine dinucleotide (FAD) and heme C as prosthetic groups, respectively.
Cat. No.: HY-E70989A
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D-Fructose Dehydrogenase, Gluconobacter industrius (EC 1.1.99.11) is a heterotrimeric membrane-bound enzyme commonly seen in various Gluconobacter sp. especially in Gluconobacter japonicus (Gluconobacter industrius) .D-Fructose Dehydrogenase consists of subunits I (67kDa), II (51 kDa), and III (20 kDa) and catalyzes the oxidation of D-fructose to produce 5-keto-D-fructose. D-Fructose Dehydrogenase is a flavoprotein-cytochrome c complex with subunits I and II covalently bound to flavin adenine dinucleotide (FAD) and heme C as prosthetic groups, respectively.
Cat. No.: HY-110282R
CAS No.: 890888-12-7
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S3QEL-2 (Standard) is the analytical standard of S3QEL-2 (HY-110282). This product is intended for research and analytical applications. S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation .
Cat. No.: HY-124940
CAS No.: 446877-42-5
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CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (IKr) and the L-type calcium channel (ICa,L), with an IC50 value of 0.909 μM for ICa,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes .
Cat. No.: HY-L944
11028 compounds
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity.
According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs.
MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
