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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
90 Results for "
Complex III
" in MedChemExpress (MCE) Product Catalog:
Products (90)
90 Results for "Complex III" in MCE Product Catalog:
Cat. No.: HY-174393
CAS No.: 1620442-30-9
Target:
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Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Qo site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain .
Cat. No.: HY-115945
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Complex III-IN-1 (Compd 4c-2) is a complex III inhibitor. Complex III-IN-1 shows antifungal activity with an EC50 of 18.53 mg/L against sclerotinia sclerotiorum .
Cat. No.: HY-115946
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Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC50 of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively .
Cat. No.: HY-125776R
CAS No.: 143390-89-0
Synonyms: BAS 490 F (Standard)
Research Areas:
Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme .
Cat. No.: HY-W112277
CAS No.: 36995-20-7
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5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride is a type of metalloporphyrin complex that features iron(III) at its core.
Cat. No.: HY-115853A
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Pyclen dihydrochloride forms kinetically and thermodynamically stable nine-coordinate Ln (III) complexes, as well as Mn (II)-based MRI contrast agents. Pyclen-Based Mn(II) Complexes can be used for liver-specific MRI .
Cat. No.: HY-123562
CAS No.: 442567-43-3
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GNF7686 is a cytochrome b inhibitor. GNF7686 exhibits inhibitory activity against complex III in the extracts of L. donovani and T. cruzi .
Cat. No.: HY-130055R
CAS No.: 341-88-8
Category:
Cat. No.: HY-148340
CAS No.: 185675-92-7
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24RBPyBC is a dinucleating macrocyclic ligand, it contains phenolate pyridine, bipyridine, and amino groups form dinuclear Fe(II) and Fe(III) complexes .
Cat. No.: HY-119687R
CAS No.: 149877-41-8
Target:
Reference Standards GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide
Research Areas:
Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
Cat. No.: HY-162463
CAS No.: 3033235-42-3
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Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot tumors." Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor .
Cat. No.: HY-W725476
Cat. No.: HY-172115
BGC4 is a biphenyl-based gold(III) complex. BGC4 inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity (IC50 for MDA-MB-231 is 5.4 μM), and induces apoptosis. BGC4 exhibits antitumor efficacy in mouse models .
Cat. No.: HY-136898
CAS No.: 86356-77-6
PS-915 dihydrochloride is a peptide substrate used in a colorimetric assay for plasma antithrombin III (ATIII). PS-915 dihydrochloride is highly specific for thrombin. By enzyme hydrolysis, PS-915 dihydrochloride liberates 3-carboxy-4-hydroxyaniline (CHA), which turns blue in color due to the complex formation with added alkaline-pentacyanoammine ferroate .
Cat. No.: HY-163337
CAS No.: 3020687-94-6
Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III .
Cat. No.: HY-19877
CAS No.: 958457-44-8
GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies .
Cat. No.: HY-176762
CAS No.: 67047-17-0
Target:
TOP3B-IN-1 (NSC-260610) is a Topoisomerase IIIβ (TOP3B) inhibitor. TOP3B-IN-1 fails to induce the formation of TOP3B cleavage complexes (TOP3Bccs) with both DNA and RNA, and destabilizes TOP3Bccs. TOP3B-IN-1 can be used as a control compound for the development of inhibitors targeting TOP3B .
Cat. No.: HY-113232S
CAS No.: 1276197-31-9
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3-Methylcrotonylglycine-d2 is the deuterated-labeled 3-Methylcrotonylglycine (HY-113232). 3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na +, K +-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency .
Cat. No.: HY-E70305
CAS No.: 84012-69-1
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GlcNAc-1-Phosphotransferase is a Golgi membrane-bound glycosylphosphotransferase. GlcNAc-1-Phosphotransferase is composed of an α/β catalytic subunit encoded by the GNPTAB gene and a γ regulatory subunit encoded by the GNPTG gene, forming an α2β2γ2 hexameric complex. GlcNAc-1-Phosphotransferase catalyzes the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the C-6 hydroxyl group of terminal mannose residues on high-mannose-type N-glycans, thereby initiating the mannose-6-phosphate tagging pathway. GlcNAc-1-Phosphotransferase loss-of-function mutations can lead to lysosomal storage diseases such as mucolipidosis type II/III. GlcNAc-1-Phosphotransferase can be used in research related to mucolipidosis .
Cat. No.: HY-138185
CAS No.: 158792-24-6
Synonyms: SF 2738A
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s=0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50=56.6 μM) but not MDA-MD-231 breast cancer cells (IC50=>100 μM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae in a model of neuronal cell death induced by all-trans retinoic acid.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
