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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
142 Results for "
Syk
" in MedChemExpress (MCE) Product Catalog:
Products (142)
142 Results for "Syk" in MCE Product Catalog:
Cat. No.: HY-184415
Research Areas:
Syk/HDAC6-IN-1 is a dual SYK/HDAC6 selective inhibitor with IC50 values of 0.19 nM (SYK) and 0.66 nM (HDAC6). Syk/HDAC6-IN-1 downregulates p-SYK to block downstream AKT/FOXO1 signaling, elevates acetylated histone H3 and α-tubulin via HDAC suppression, represses SREBF1 -mediated lipid biosynthetic pathways, triggers G0/G1 cell cycle arrest and robust mitochondrial-dependent caspase-3-mediated apoptosis in leukemia cells. Syk/HDAC6-IN-1 can be used for the research of FLT3-mutant acute myeloid leukemia .
Cat. No.: HY-18911
CAS No.: 1419299-81-2
Target:
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Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC50 of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma .
Cat. No.: HY-125500
CAS No.: 1630203-25-6
Research Areas:
TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome .
Cat. No.: HY-15968A
CAS No.: 1648797-46-9
Synonyms: GS-9973 dimesylate
Target:
Research Areas:
Entospletinib dimesylate (GS-9973 dimesylate) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM .
Cat. No.: HY-109091R
CAS No.: 1800046-95-0
Synonyms: GS-9876 (Standard)
Target:
Research Areas:
Lanraplenib (Standard) is the analytical standard of Lanraplenib (HY-109091). This product is intended for research and analytical applications. Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .
Cat. No.: HY-109091BR
CAS No.: 1800047-00-0
Synonyms: GS-9876 succinate (Standard)
Target:
Research Areas:
Lanraplenib succinate (Standard) is the analytical standard of Lanraplenib (succinate) (HY-109091B). This product is intended for research and analytical applications. Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate (GS-9876 succinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .
Cat. No.: HY-100867AR
CAS No.: 1952251-28-3
Synonyms: TAK-659 monohydrochloride (Standard); CB-659 monohydrochloride (Standard)
Target:
Research Areas:
Mivavotinib (monohydrochloride) (Standard) is the analytical standard of Mivavotinib (monohydrochloride) (HY-100867A). This product is intended for research and analytical applications. TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .
Cat. No.: HY-103018R
CAS No.: 1425381-60-7
Synonyms: ASN-002 (Standard)
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Gusacitinib (Standard) is the analytical standard of Gusacitinib (HY-103018). This product is intended for research and analytical applications. Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .
Cat. No.: HY-12067R
CAS No.: 841290-81-1
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Research Areas:
R406 (Standard) is the analytical standard of R406 (HY-12067). This product is intended for research and analytical applications. R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk Kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
Cat. No.: HY-156196
CAS No.: 1810059-82-5
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BI 894416 is a spleen tyrosine kinase (SYK) inhibitor. BI 894416 has a deuterium-labeled derivative that can be used as an internal standard for bioanalytical studies. BI 894416 is applicable to the research of severe asthma .
Cat. No.: HY-184063
CAS No.: 2230362-69-1
Synonyms: Vexicitinibum
Research Areas:
Vexicitinib (Vexicitinibum) is a SYK and JAK2 inhibitor with IC50 values both less than 10 nM. Vexicitinib exhibits anti-inflammatory and immunosuppressive effects . Vexicitinib can be used in tumor-related research .
Cat. No.: HY-112319A
CAS No.: 1312518-85-6
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Research Areas:
MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
