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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
142 Results for "
Syk
" in MedChemExpress (MCE) Product Catalog:
Products (142)
142 Results for "Syk" in MCE Product Catalog:
Cat. No.: HY-174284
CAS No.: 1360905-04-9
Target:
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Syk-IN-13 (Compound A90) is a Syk inhibitor, and can be used for research of rheumatoid arthritis and/or systemic lupus .
Cat. No.: HY-112390B
CAS No.: 1965323-05-0
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Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect .
Cat. No.: HY-RS14075
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SYK Human Pre-designed siRNA Set A contains three designed siRNAs for SYK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14076
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Syk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Syk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14077
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Syk Rat Pre-designed siRNA Set A contains three designed siRNAs for Syk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-169630
CAS No.: 314027-66-2
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DBMB is an inhibitor of spleen tyrosine kinase (Syk), capable of significantly inhibiting the activity of Syk kinase. DBMB exhibits anti-inflammatory activity by suppressing the signaling of NF-κB, which in turn reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases .
Cat. No.: HY-109091A
CAS No.: 1800046-97-2
Synonyms: GS-9876 monosuccinate
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Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans .
Cat. No.: HY-120214
CAS No.: 1429038-15-2
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TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases .
Cat. No.: HY-103018S
Synonyms: ASN-002-d4
Cat. No.: HY-162257
CAS No.: 3016419-52-3
BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway .
Cat. No.: HY-123625
CAS No.: 1620142-65-5
Synonyms: R-932348 choline
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R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection .
Cat. No.: HY-180212A
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SYK-1106 dihydrochloride is a selective δ opioid receptor (DOR) agonist with an EC50 of 0.089 nM. SYK-1106 dihydrochloride shows high selectivity over MOR and KOR. SYK-1106 dihydrochloride exhibits antidepressant-like effects in the mouse forced-swimming tests. SYK-1106 dihydrochloride can be used for the research of depression .
Cat. No.: HY-180212
CAS No.: 2643940-93-4
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SYK-1106 is a potent delta-opioid receptor (DOR) agonist with an EC50 of 89 pM and a Ki of 848 pM. SYK-1106 is selective for μ and κ opioid receptors, with Ki values of 9.54 nM and 2.45 nM, respectively. SYK-1106 induces dose-dependent antidepressant-like effects. SYK-1106 can be used for the research of depression .
Cat. No.: HY-183924
CAS No.: 725237-11-6
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SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC50 of 0.006 μM, human ZAP-70 IC50 of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases .
Cat. No.: HY-184655
CAS No.: 3102293-90-0
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Syk-IN-16 is a spleen tyrosine kinase (SYK) inhibitor with an IC50 of 16.0 nM. Syk-IN-16 exerts antiproliferative effects, induces cell apoptosis, inhibits cell migration and increases DNA damage in cancer cells. Syk-IN-16 suppresses tumor growth in xenograft models without obvious toxicity. Syk-IN-16 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-184306
SYK-IN-15 is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 10.9 nM. SYK-IN-15 induces cell cycle S-phase arrest and cell apoptosis. SYK-IN-15 inhibits cancer cell colony formation and exerts antiproliferative effects on cancer cells. SYK-IN-15 can be used for the research of solid tumors (ovarian cancer, breast cancer, liver cancer) .
Cat. No.: HY-P701638
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Syk; Tyrosine-Protein Kinase Syk; Spleen Associated Tyrosine Kinase; P72-Syk; Spleen Tyrosine Kinase; IMD82
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701637
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Syk; Tyrosine-Protein Kinase Syk; Spleen Associated Tyrosine Kinase; P72-Syk; Spleen Tyrosine Kinase; IMD82
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
