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Cat. No.: HY-162257

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BTK-IN-34

BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway.

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CAS No.: 3016419-52-3
화학식: C₂₂H₂₉N₃O₄S
분자량:431.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BTK-IN-34 Chemical Structure

CAS No.: 3016419-52-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

BTK-IN-34 (compound 9h; 1-50 μM; 24 hours) decreases the pBTK, pERK 1/2 (Thr202/Tyr204), and p-p38 (Thr180/Tyr182) levels in RAMOS cells^[1].
BTK-IN-34 (compound 9h) displays selective cytotoxicity against BTK-high RAMOS cells with an IC₅₀ of 2.75 μM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAMOS cells
Concentration:

1 μM, 10 μM, 50 μM
Incubation Time:

24 hours
Result:

Decreased pBTK (Tyr223) levels.

Chemical Information

CAS No. 3016419-52-3
분자량 431.55
화학식 C₂₂H₂₉N₃O₄S
SMILES

O=C1NC2=C(C=C(S(=O)(N3CCN(C(CCCC)=O)CC3)=O)C=C2)/C1=C4CCCC\4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vani Madhuri Velavalapalli, et al. Novel 5-Substituted Oxindole Derivatives as Bruton’s Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation. ACS Omega 2024, 9, 7, 8067-8081.

Calculators

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Mass Mass

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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