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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
140 Results for "
Configuration
" in MedChemExpress (MCE) Product Catalog:
Products (140)
140 Results for "Configuration" in MCE Product Catalog:
Cat. No.: HY-N21956
CAS No.: 96657-95-3
Target:
Cat. No.: HY-121125
CAS No.: 64274-28-8
Category:
Plantaginaceae Iridoids Terpenoids Plants Pseudolysimachion linariifolium subsp. dilatatum (Nakai & Kitag.) D. Y. Hong
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Cat. No.: HY-169946A
CAS No.: 3047759-59-8
WEE1/PKMYT1-IN-2 is the axial chiral P configuration of WEE1/PKMYT1-IN-1 (HY-169946). WEE1/PKMYT1-IN-1 is a potent and orally active WEE1 and PKMYT1 inhibitor. WEE1/PKMYT1-IN-1 shows antiproliferation activity .
Cat. No.: HY-169946B
CAS No.: 3047759-60-1
WEE1/PKMYT1-IN-3 is the axial chiral M configuration of WEE1/PKMYT1-IN-1 (HY-169946). WEE1/PKMYT1-IN-1 is a potent and orally active WEE1 and PKMYT1 inhibitor. WEE1/PKMYT1-IN-1 shows antiproliferation activity .
Cat. No.: HY-113068R
CAS No.: 148-03-8
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Cat. No.: HY-113756B
CAS No.: 2699713-95-4
Research Areas:
rel-Latanoprost acid is a relative configuration of Latanoprost acid (HY-113756A). Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
Cat. No.: HY-142648A
CAS No.: 1832577-07-7
(R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies .
Cat. No.: HY-164254
CAS No.: 2351906-71-1
Synonyms: (E/Z)-GA-002
Target:
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Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP .
Cat. No.: HY-169803
CAS No.: 113243-00-8
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L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
Cat. No.: HY-170437
CAS No.: 2976336-81-7
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MOR modulator-1 (compound 6) is a potent and selective μ opioid receptor (MOR) modulator. MOR modulator-1 exhibits improved opioid receptor selectivity, enhanced in vivo antagonistic effect, and overall fewer withdrawal symptoms compared to NAT (6α-configuration). MOR modulator-1 links with carboxamido linker μ, δ, γ with Kis of 0.25, 41.1, 1.30 nM, respectively[1]
Cat. No.: HY-N21864
CAS No.: 1303438-53-0
Category:
Flavonoids Flavonones Plants Moraceae Morus cathayana Hemsl.
Target:
Cat. No.: HY-136926
CAS No.: 58591-23-4
Synonyms: FR-008I
Candicidin A3 (FR-008I) is an antifungal antibiotic with significant biological activity. Candicidin A3 can effectively inhibit the growth of fungi through its unique three-dimensional structure and seven-membered ring geometry. The absolute configuration of Candicidin A3 is a specific arrangement of multiple chiral centers, which may affect its biological activity and interaction with targets. Candicidin A3 can be used as a potential drug to inhibit fungal infections .
Cat. No.: HY-138642B
CAS No.: 2614417-52-4
Synonyms: rel-ARV-471; rel-PF-07850327
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Research Areas:
(Rac)-Vepdegestrant is the relative configuration of Vepdegestrant (HY-138642). Vepdegestrant is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
Cat. No.: HY-176193
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P-gp modulator-7 (Compound 9e) is a P-glycoprotein (P-gp) inhibitor. P-gp modulator-7 occupies the channel entrance of P-gp with a unique T-shaped configuration, hindering the peristaltic extrusion mechanism of transmembrane domains TM12 and TM9, thereby inhibiting P-gp from pumping drugs out of cells and reversing the multidrug resistance (MDR) of tumor cells. P-gp modulator-7 is promising for research of cancers .
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Cat. No.: HY-W742083
CAS No.: 131064-75-0
Research Areas:
(R,R)-Benazepril is the R configuration of Benazepril (HY-B0093). Benazepril (CGS14824A free base) is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces the production of angiotensin II. Benazepril inhibits oxidative stress and suppresses apoptosis through the PI3K/Akt signaling pathway. Benazepril effectively ameliorates diabetic nephropathy and reduces proteinuria. Benazepril is used in the study of hypertension, heart failure, and diabetic nephropathy .
Cat. No.: HY-W753181
Synonyms: L-(-)-3-Phenyllactic Acid-13C9
Cat. No.: HY-N19839
CAS No.: 141897-12-3
Synonyms: Stratioside II
Category:
Phyllanthaceae Glochidion zeylanicum (Gaertn.) A. Juss. Plants Saccharides Monosaccharides
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Cat. No.: HY-N21578
CAS No.: 151201-78-4
Category:
Actaea heracleifolia (Kom.) J. Compton Terpenoids Ranunculaceae Plants Pentacyclic Triterpenoids
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Cat. No.: HY-118132
CAS No.: 36431-52-4
Target:
Research Areas:
LL-Z1220 is a novel antibiotic with the structure of 2-(3,8-dioxopentacyclo[5.1.0.0^~^~]oct-5-en-5-yl)-4H-pyran-4-one. This appears to be the first reported natural product containing a benzene dioxide group. This antibiotic readily undergoes valence isomerization to form 1,4-dioxopentacyclo. The chemical and spectroscopic properties of the antibiotic suggest that the benzene dioxide has a cis configuration.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
