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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
149 Results for "
MCP
" in MedChemExpress (MCE) Product Catalog:
Products (149)
149 Results for "MCP" in MCE Product Catalog:
Target:
Pyruvate Kinase COX STAT TNF Receptor NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase
Research Areas:
Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .
Cat. No.: HY-19020
CAS No.: 94936-90-0
Target:
Research Areas:
FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure .
Cat. No.: HY-178471
CAS No.: 2975215-64-4
Target:
Research Areas:
FABP4/5-IN-6 is an orally active, potent FABP4/5 inhibitor (Ki = 0.41/2.53 μM), showing low selectivity over FABP3 (Ki = 59.72 μM). FABP4/5-IN-6 inhibits the secretion of MCP-1 and IL-6 in Lipopolysaccharides (HY-D1056) (LPS)-induced THP-1 macrophage. FABP4/5-IN-6 exhibits significant anti-inflammatory effects and attenuates LPS-induced liver injury. FABP4/5-IN-6 has low hERG inhibition (LD50 > 2000 mg/kg). FABP4/5-IN-6 can be used for the study of Inflammation-related diseases .
Cat. No.: HY-N0847R
CAS No.: 68370-47-8
Target:
Cat. No.: HY-W753956
CAS No.: 3044090-39-0
Cat. No.: HY-P700164AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P700231AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Pig
Source:
E. coli
Cat. No.: HY-P2969
CAS No.: 80295-66-5
Target:
Research Areas:
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .
Synonyms: Malvidin-3-O-glucoside chloride; Oenin chloride
Cat. No.: HY-13324R
CAS No.: 218600-53-4
Synonyms: RTA 402 (Standard); NSC 713200 (Standard); CDDO Methyl ester (Standard)
Research Areas:
Bardoxolone methyl (Standard) is the analytical standard of Bardoxolone methyl (HY-13324). This product is intended for research and analytical applications. Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic Kidney disease (CKd) .
Cat. No.: HY-13324S
Synonyms: RTA 402-d3; NSC 713200-d3; CDDO Methyl ester-d3
Research Areas:
Bardoxolone methyl-d3 (RTA 402-d3) is the deuterated-labeled Bardoxolone methyl (HY-13324). Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .
Synonyms: ADX-629
Target:
Research Areas:
Acloproxalap (ADX-629) is an orally active reactive aldehyde species (RASP) inhibitor. Acloproxalap binds covalently to free aldehydes, sequesters reactive aldehyde species, malondialdehyde, acetaldehyde and preformed malondialdehyde-acetaldehyde adducts, and reduces elevated RASP levels. Acloproxalap decreases the formation of aldehyde adducts, reduces liver and serum triglyceride levels, hepatic fat accumulation, circulating anti-malondialdehyde-acetaldehyde adduct antibody levels, and inhibits the release of IL-6 and MCP-1. Acloproxalap improves cell viability of liver slices exposed to ethanol. Acloproxalap blocks ethanol-induced damage in animal models of alcoholic liver disease. Acloproxalap is applicable to research related to alcoholic liver disease, alcoholic fatty liver disease, non-alcoholic steatohepatitis, chronic cough, rheumatoid arthritis, ulcerative colitis and mild atopic asthma .
Cat. No.: HY-125740R
CAS No.: 7228-78-6
Synonyms: Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)
Cat. No.: HY-P706002
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; Zinc Finger CCCH-Type Containing 12A; Regnase-1; MCPIP1; Monocyte Chemotactic Protein-Induced Protein 1; Zinc Finger CCCH Domain-Containing Protein 12A; Endoribonuclease ZC3H12A; MCP-Induced Protein 1; FLJ23231; MCPIP-1; MCPIP; Reg1; Bifunctional Endoribonuclease And Deubiquitinase ZC3H12A; MCP-1 Treatment-Induced Protein; MCP Induced Protein 1; Ribonuclease ZC3H12A; DJ423B22.1
Species:
Human
Source:
E. coli
Cat. No.: HY-P77589
Purity: ≥ 95%, as determined by HPLC.
Synonyms: CCR2; CCR-2; Prev. CMKBR2; Chemokine Receptor 2; CC-CKR-2; MCP-1 Receptor; MCP-1-R; CD192 Antigen; C-C Chemokine Receptor Type 2; C-C CKR-2; CD192; CCR2A; CKR2; CCR2B; Monocyte Chemoattractant Protein 1 Receptor; CKR2A; Chemokine (C-C Motif) Receptor 2; C
Species:
Human
Source:
HEK293
Cat. No.: HY-P77590
Purity: ≥ 95%, as determined by HPLC.
Synonyms: CCR2; CCR-2; Prev. CMKBR2; Chemokine Receptor 2; CC-CKR-2; MCP-1 Receptor; MCP-1-R; CD192 Antigen; C-C Chemokine Receptor Type 2; C-C CKR-2; CD192; CCR2A; CKR2; CCR2B; Monocyte Chemoattractant Protein 1 Receptor; CKR2A; Chemokine (C-C Motif) Receptor 2; C
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
