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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
166 Results for "
FMS
" in MedChemExpress (MCE) Product Catalog:
Products (166)
166 Results for "FMS" in MCE Product Catalog:
Cat. No.: HY-10204R
CAS No.: 728033-96-3
OSI-930 (Standard) is the analytical standard of OSI-930 (HY-10204). This product is intended for research and analytical applications. OSI-930 is an orally selective inhibitor of Kit, KDR and CSF-1R (c-Fms) with IC50s of 80 nM, 9 nM and 15 nM, respectively. OSI-930 also moderately inhibits Flt-1, c-Raf, Lck and low activity against PDGFRα/β, Flt-3 and Abl. OSI-930 has antitumor activity .
Cat. No.: HY-10408R
CAS No.: 623142-96-1
Target:
Research Areas:
Ki20227 (Standard) is the analytical standard of Ki20227 (HY-10408). This product is intended for research and analytical applications. Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
Cat. No.: HY-118304A
CAS No.: 1175017-91-0
AKN-028 TFA, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 TFA inhibits FLT3 autophosphorylation. AKN-028 TFA induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 TFA induces apoptosisby activation of caspase 3. AKN-028 TFA can be used in research of acute myeloid leukemia (AML) .
Cat. No.: HY-E70724
FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays important roles in cell survival, proliferation, and differentiation during normal hematopoiesis. FLT3 is one of the most frequently mutated genes in acute myeloid leukemia (AML). FLT3 ITD is a internal tandem duplication (ITD) mutation of FLT3 that may be present in AML cells. FLT3 ITD Recombinant Human Active Protein Kinase is a recombinant FLT3 ITD protein that can be used to study FLT3 ITD-related functions .
Cat. No.: HY-P74466
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74467
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74468
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Human
Source:
HEK293
Cat. No.: HY-P74469
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Human
Source:
HEK293
Cat. No.: HY-P78538
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Human
Source:
HEK293
Cat. No.: HY-P78872
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Human
Source:
HEK293
Cat. No.: HY-P704278
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT4; FMS Related Tyrosine Kinase 4; FMS Related Receptor Tyrosine Kinase 4; VEGF Receptor-3; VEGFR3; FLT-4; Vascular Endothelial Growth Factor Receptor 3; Vascular Endothelial Growth Factor Receptor 3 Variant; VEGFR-3; Alternative Protein FLT4; Tyrosine-
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P83460A
Synonyms: M-CSF Receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-FMS; CD115
Cat. No.: HY-184574
HDAC-IN-104 is a potent and selective class I Histone deacetylases (HDAC) inhibitor with an IC50 of 25 nM. HDAC-IN-104 exerts potent antiproliferative and antitumor effects by inhibiting glycolysis and OXPHOS via blockade of the PI3K/AKT signaling pathway, and these effects are synergistically enhanced when combined with the FMS-like tyrosine kinase 3 (FLT3) inhibitor Quizartinib (AC220) (HY-13001). HDAC-IN-104 induces significant early and late apoptosis. HDAC-IN-104 can be used for acute myeloid leukemia (AML) research .
Cat. No.: HY-10032R
CAS No.: 952021-60-2
Synonyms: PF 00477736 (Standard)
Research Areas:
PF 477736 (PF 00477736) (Standard) is the analytical standard of PF 477736 (HY-10032). This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo .
Cat. No.: HY-175473
CAS No.: 898168-15-5
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC50 values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication
(FLT3-|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML) .
Cat. No.: HY-E70723
FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays important roles in cell survival, proliferation, and differentiation during normal hematopoiesis. FLT3 is one of the most frequently mutated genes in acute myeloid leukemia (AML). FLT3 D835Y is the most frequent kinase domain mutation, converting aspartic acid to tyrosine. FLT3 D835Y Recombinant Human Active Protein Kinase is a recombinant FLT3 D835Y protein that can be used to study FLT3 D835Y-related functions .
Cat. No.: HY-P72949U
Purity: ≥ 95%, as determined by reducing SDS-PAGE.; ≥ 95%, as determined by HPLC.
Synonyms: Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
