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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
643 Results for "
SCO2 mutations
" in MedChemExpress (MCE) Product Catalog:
Products (643)
643 Results for "SCO2 mutations" in MCE Product Catalog:
Cat. No.: HY-E70640
The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate (HY-50946) binding capacity, thus contributing to Imatinib Mesylate resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML). ABL1 T315I Recombinant Human Active Protein Kinase is a recombinant ABL1 T315I protein that can be used to study ABL1 T315I-related functions .
Cat. No.: HY-E70641
The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate (HY-50946) binding capacity, thus contributing to Imatinib Mesylate resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML). ABL1 Y253F Recombinant Human Active Protein Kinase is a recombinant ABL1 Y253F protein that can be used to study ABL1 Y253F-related functions .
Cat. No.: HY-E70783
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TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y1108F is the most mutation of TIE2. TIE2 Y1108F Recombinant Human Active Protein Kinase is a recombinant TIE2 Y1108F protein that can be used to study TIE2 Y1108F-related functions .
Cat. No.: HY-E70784
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TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y897S is the most mutation of TIE2. TIE2 Y897S Recombinant Human Active Protein Kinase is a recombinant TIE2 Y897S protein that can be used to study TIE2 Y897S-related functions .
Cat. No.: HY-171732
CAS No.: 24554-26-5
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FANFT is an orally active and potent uroepithelial carcinogen. FANFT is metabolized to ANFT in vivo, which induces gene mutations and malignant cell transformation. FANFT efficiently induces bladder tumors in mice .
Cat. No.: HY-E70733
JAK1 belongs to Janus family kinases (JAK) family. JAK mediates the Stat activation by cytokines. Jak1 is involved in IL-6-stimulated Stat3 activity. JAK1S729C mutations is proved to be activating mutations in vitro. JAK1 S729C Recombinant Human Active Protein Kinase is a recombinant JAK1 S729C protein that can be used to study JAK1 S729C-related functions .
Cat. No.: HY-E70782
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TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 R849W is the most common mutation implicated in an inherited form of vascular malformations. TIE2 R849W Recombinant Human Active Protein Kinase is a recombinant TIE2 R849W protein that can be used to study TIE2 R849W-related functions .
Cat. No.: HY-134301A
Synonyms: 8-Ethylthio-NAD+ sodium
8-ET-NAD+ (sodium) is the derivative of NAD+. 8-ET-NAD+ (sodium) can be used in screening of PARP1 gatekeeper mutations. 8-ET-NAD+ (sodium) can be studied in research on cancer .
Cat. No.: HY-114253
CAS No.: 2130982-18-0
ODS-2004436 is a small molecule radiotracer that uses positron emission tomography (PET) imaging to measure the activity of the epidermal growth factor receptor (EGFR) in tumors. ODS-2004436 labeled with the radioactive isotope fluorine-18 shows significantly higher uptake in the xenograft models of lung cancer with EGFR mutations compared to the wild-type models, and could be used to distinguish the mutation status. ODS-2004436 can be used to identify EGFR-positive tumors and predict their response to certain reagent treatments, especially for non-small cell lung cancer (NSCLC) .
Cat. No.: HY-143616
CAS No.: 2659225-28-0
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EZH2-IN-7 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-7 has the potential for the research of cancer diseases (extracted from patent WO2021129629A1, compound 259) .
Cat. No.: HY-E70843
MAP2K1 encodes mitogen-activated protein kinase 1 (MEK1), which is a key component in the RAS-mitogen-activated protein kinase kinase (RAS/MAPK) signal transduction pathway. MAP2K1 P124L mutation is a mild mutation. MAP2K1 P124L Recombinant Human Active Protein Kinase is a recombinant MAP2K1 P124L protein that can be used to study MAP2K1 P124L-related functions .
Cat. No.: HY-106791
CAS No.: 107740-67-0
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CGP 31608 is a semisynthetic penem derivative with antibacterial activity. CGP 31608 is resistant to many important beta-lactamases (including the mutationally derepressed chromosomal enzymes). CGP 31608 can be used for the research of infection .
Cat. No.: HY-165438
CAS No.: 360775-96-8
Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
Cat. No.: HY-P5369
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Cat. No.: HY-P5365
CAS No.: 374796-72-2
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Cat. No.: HY-112870AS
Synonyms: Alflutinib-d3 mesylate; Furmonertinib-d3 mesylate; AST2818-d3 mesylate
Cat. No.: HY-187863
CAS No.: 2991354-62-0
Debecarasib is a KRAS inhibitor. Debecarasib exhibits antitumor activity and can be used in research on KRAS mutation-driven cancers.
Cat. No.: HY-N17457
CAS No.: 111017-06-2
Category:
Alkaloids Plant Other Alkaloids Menispermaceae Extract Tinospora crispa (L.) Hook. f. et Thoms Extract
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Cat. No.: HY-185276
CAS No.: 2989904-86-9
EGFR-IN-204 (Example 1) is a HER2 exon 20 mutation inhibitor with selectivity for wild-type EGFR. EGFR-IN-204 exerts antiproliferative effects on cells dependent on HER2 exon 20 YVMA insertion mutation and wild-type HER2, and shows strong selectivity over cells dependent on wild-type EGFR. EGFR-IN-204 is applicable to non-small cell lung cancer research .
Cat. No.: HY-190792
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TrkA-IN-24 is a potent covalent TRKA inhibitor with an IC50 of 23.1 nM and a Ki of 1.48 µM against TRKA-G595R. TrkA-IN-24 overcomes the acquired resistance to Larotrectinib (HY-12866) caused by such mutations by covalently targeting and modifying the arginine residue Arg595 newly introduced by the mutation in the mutant TRKA kinase. TrkA-IN-24 can be used for research on TRKA-mutant tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
