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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
593 Results for "
SCO2 mutations
" in MedChemExpress (MCE) Product Catalog:
Products (593)
593 Results for "SCO2 mutations" in MCE Product Catalog:
Cat. No.: HY-P99462A
Synonyms: CDX-0159 (LALQ-KQ, YTE)
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Barzolvolimab (CDX-0159) (LALQ-KQ, YTE) is a humanized anti-KIT IgG1 monoclonal antibody. It incorporates the L234A/L235Q/K322Q mutations to silence Fc effector functions, while also featuring the M252Y/S254T/T256E mutations to extend its half-life. Barzolvolimab (LALQ-KQ, YTE) can reduce cutaneous mast cell counts and disease activity in chronic inducible urticaria.
Cat. No.: HY-18957C
CAS No.: 2025320-97-0
Synonyms: BGB-283 hydrochloride
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Lifirafenib hydrochloride (BGB-283 hydrochloride) is a novel, reversible B-RAFV600E inhibitor with antitumor activity. Lifirafenib has shown potent antitumor activity against solid tumors with B-RAFV600E mutations, such as melanoma, thyroid cancer, and low-grade serous ovarian cancer. Lifirafenib exhibits selective cytotoxicity in vitro, preferentially inhibiting the proliferation of cancer cells with B-RAFV600E and EGFR mutations/amplification. Lifirafenib can achieve dose-dependent inhibition of tumor growth in animal models, accompanied by partial and complete tumor shrinkage .
Cat. No.: HY-181701
CAS No.: 3077345-85-5
EGFR-IN-202 is an epidermal growth factor receptor (EGFR) inhibitor that selectively targets EGFR exon 20 insertion mutations. EGFR-IN-202 can be used in research related to non-small cell lung cancer .
Cat. No.: HY-137516A
CAS No.: 2502156-12-7
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .
Cat. No.: HY-164464
CAS No.: 1644502-33-9
BPI-15086 an orally active, potent, irreversible mutant-selective inhibitor of both EGFR and T790M resistance mutations tyrosine kinase. BPI-15086 can be used for the research of non-small-cell lung cancer .
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Lithium citrate is a lithium supplement that reduces excess brain N-acetylaspartate (NAA) in Canavan disease. Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the aspartate acylase (ASPA) gene, which catalyzes the hydrolysis of N-acetylaspartate (NAA) to acetate and aspartate .
Cat. No.: HY-156803
CAS No.: 144082-88-2
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Estradiol 3,4-quinone (E2-3,4-Q) is a metabolite of Estradiol (HY-B0141). Estradiol 3,4-quinone is a highly electrophilic compound and can induce cancer initiating mutations .
Cat. No.: HY-167948
CAS No.: 1262034-38-7
Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).
Cat. No.: HY-P992522
Human IgG1 (M252Y/S254T/T256E) kappa, Isotype Control is an engineered Fc (YTE mutation) human IgG1 κ isotype control antibody.
Cat. No.: HY-152852S
Synonyms: Mifanertinib-d6
Cat. No.: HY-184397
P53-Y220C stabilizer-1 as an indole-based p53-Y220C stabilizer (EC50 = 0.46 μM) that engages the mutation-induced cavity. P53-Y220C stabilizer-1 binds the p53-Y220C mutant with high affinity (KD = 56 nM) and acts as a selective indole-based p53-Y220C stabilizer that engages the mutation-induced cavity. P53-Y220C stabilizer-1 increases mutant protein thermal stability and restores p53 transcriptional activity, mainly triggering cell cycle arrest instead of acute apoptosis. P53-Y220C stabilizer-1 can be applied to cancers harboring the p53-Y220C mutation, such as gastric cancer .
Cat. No.: HY-111249
CAS No.: 871037-95-5
TTT 3002 is a potent and orally active FLT3 inhibitor. TTT 3002 potently inhibits FLT3 phosphorylation by activating mutations at residue D835, with an IC50 of 0.2 nM. TTT 3002 can be used for AML (acute myeloid leukemia) research .
Cat. No.: HY-156700
CAS No.: 2619512-84-2
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Lenalidomide-acetylene-Br is a PROTAC Linker taht makes up HJM-561 (HY-156698). HJM-561 is a potent, selective, and orally active EGFR PROTAC to inhiibit Osimertinib (HY-15772)-resistant EGFR triple mutations.
Metazide is an antitubercular agent with non-mutagenic properties. Metazide does not induce gene mutations in Salmonella typhimurium tester strains TA 1950 and TA 1538 with in vitro metabolic activation via modified Ames plate technique. Metazide can be used for the research of tuberculosis .
Cat. No.: HY-P10610
CAS No.: 155314-25-3
Cat. No.: HY-P3129
CAS No.: 145019-94-9
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Cat. No.: HY-108845
CAS No.: 191588-94-0
Synonyms: TNK-tPA
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Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke [2].
SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
