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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
604 Results for "
SCO2 mutations
" in MedChemExpress (MCE) Product Catalog:
Products (604)
604 Results for "SCO2 mutations" in MCE Product Catalog:
Cat. No.: HY-108845
CAS No.: 191588-94-0
Synonyms: TNK-tPA
Target:
Domaines de recherche:
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke [2].
SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research .
Target:
Domaines de recherche:
AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells [2].
Cat. No.: HY-145691
CAS No.: 381173-58-6
HP1142 is a potent and selective inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1142 is a benzoimidazole scaffold-based compound. HP1142 has the potential for the research of FLT3/ITD leukemia .
Cat. No.: HY-146997
CAS No.: 2770681-85-9
Target:
Domaines de recherche:
TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH) .
Cat. No.: HY-16743C
CAS No.: 1629063-79-1
Synonyms: Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride
Target:
Domaines de recherche:
Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [2].
Cat. No.: HY-186101
CAS No.: 3107623-69-5
P53 mutant stabilizer-1 (compound 274) is a covalent mutant p53 stabilizer. P53 mutant stabilizer-1 can be used for the study of wild-type function of p53 mutants, such as cancers associated with p53 mutation .
Cat. No.: HY-N0153A
CAS No.: 132203-74-8
Synonyms: Naringoside hydrate
Target:
Domaines de recherche:
Niacinamide ascorbate is a vitamin complex that combines niacinamide (vitamin B3) and ascorbic acid (vitamin C). Niacinamide ascorbate reduces the risk of radiation-induced acute leukemia, breast cancer, thyroid cancer, and other somatic and genetic mutations following exposure to ionizing radiation doses .
Synonyms: PF-00932239
Domaines de recherche:
R-IMPP (PF-00932239) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia [2] .
Cat. No.: HY-101354A
CAS No.: 2173005-10-0
Synonyms: PF-00932239 hydrochloride
Domaines de recherche:
R-IMPP hydrochloride (PF-00932239 hydrochloride) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP hydrochloride inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP hydrochloride reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP hydrochloride increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP hydrochloride inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP hydrochloride can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia [2] .
Cat. No.: HY-139621
CAS No.: 2916559-62-9
Target:
Domaines de recherche:
Colibactin 742 is a covalently binding DNA-damaging agent targeting DNA, with an IC50 of 5.2 μM against human cervical cancer cells (HeLa). Colibactin 742 covalently binds to DNA, forming interstrand crosslinks (ICLs), activating the Fanconi anemia DNA repair pathway, inducing γH2AX and FANCD2 foci formation and cell cycle arrest, while exacerbating mismatch repair deficiency (MMRd)-related mutations. Colibactin 742 can mimic the genotoxicity of natural Colibactin while avoiding its instability, and is mainly used in colorectal cancer (CRC) related research, including microbial tumorigenesis mechanisms, DNA damage repair pathways, and mutation signature analysis [2] .
Cat. No.: HY-W776973
CAS No.: 1216449-31-8
Synonyms: Oxiranecarboxamide-13C3; 2,3-Epoxypropanamide-13C3
Domaines de recherche:
Glycidamide- 13C3 (Oxiranecarboxamide- 13C3; 2,3-Epoxypropanamide- 13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide (Oxiranecarboxamide) is the genotoxic metabolite of acrylamide. Glycidamide covalently binds to adenine and guanine bases to form thermally labile depurinating Glycidamide-DNA adducts, which block polymerase progression and are promutagenic, producing mutational signatures of A-to-G transitions and G-to-C/G-to-T transversions. Glycidamide induces hprt mutations, DNA damage, micronucleus formation, cytogenetic damage, impaired proliferation kinetics, cytotoxicity, apoptosis, and regulation of apoptosis gene expression. Glycidamide can be used in cancer research [2] .
Cat. No.: HY-135815B
CAS No.: 2389149-85-1
Synonyms: TAK-788 mesylate; AP32788 mesylate
Mobocertinib (TAK-788) mesylate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib mesylate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib mesylate can be used in NSCLC research [2].
Cat. No.: HY-185930
CAS No.: 3119104-59-2
Target:
Domaines de recherche:
Reftinirsen inapertide is a CNOT3 inhibitor. CNOT3 is a non-catalytic subunit of the CCR4-NOT complex, serving as a direct transcriptional repressor and penetrance modifier of PRPF31. Reftinirsen inapertide can be used for the research of retinal dystrophies associated with prpf31 mutations .
Cat. No.: HY-P10610A
Cat. No.: HY-122018
CAS No.: 875608-25-6
Target:
Domaines de recherche:
GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation .
XMU-MP-3 is a potent non-covalent BTK inhibitor with IC50s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis .
Target:
Domaines de recherche:
NVP-BVU972 is an selective and potent Met inhibitor, with an IC50 of 14 nM. NVP-BVU972 also exhibits good anti-proliferative activity against Met with drug-resistant mutations and inhibits phosphorylation. NVP-BVU972 can be used in study of cancer .
Cat. No.: HY-P991267
Target:
Domaines de recherche:
CAN10 is a monoclonal antibody targeting IL1RAP. Unlike CAN10 (HY-P991267A), CAN10 does not contain the L234A and L235A mutations. CAN10 can be used in research concerning immune system disorders (such as systemic sclerosis) .
Cat. No.: HY-Z0275R
CAS No.: 39968-33-7
Domaines de recherche:
HOAT (Standard) is the analytical standard of HOAT (HY-Z0275). This product is intended for research and analytical applications. HOAT is a peptide bond-forming reagent. HOAT is utilized to affect formation of peptide bonds by coupling carboxylic acids with amines. HOAt is not mutagenic in the bacterial reverse mutation test .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
