SU11652
Based on 1 Customer Validation
SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research.
For research use only. We do not sell to patients.
- Purity: 99.18%
- CAS No.: 326914-10-7
- Formula: C22H27ClN4O2
- Molecular Weight:414.93
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
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All VEGFR Isoforms
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Biological Activity
IC50: 0.01 μM (PDGFR), 0.03 μM (Flk-1), 0.05 μM (c-kit)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 3T3 | IC50 |
0.1 μM
Compound: 12c
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Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation
Inhibition of Platelet-derived growth factor induced 3T3 cell proliferation
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[PMID: 12646019] |
| NIH3T3 | IC50 |
<0.07 μM
Compound: 12c
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Inhibition of PDGF-induced BrdU incorporation in 3T3 cells
Inhibition of PDGF-induced BrdU incorporation in 3T3 cells
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[PMID: 12646019] |
| NIH3T3 | IC50 |
0.05 μM
Compound: 12c
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Inhibition of Vascular endothelial growth factor receptor in 3T3 cells
Inhibition of Vascular endothelial growth factor receptor in 3T3 cells
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[PMID: 12646019] |
SU11652 (0-1 μM, 0-72 h) inhibits the growth of mast cell lines expressing mutant Kit[1].
SU11652 (0-1 μM, 0-72 h) induces cell cycle arrest followed by apoptosis in cell lines expressing mutant Kit[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 326914-10-7
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Appearance Solid
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Molecular Weight 414.93
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Formula C22H27ClN4O2
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Color Yellow to orange
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SMILES
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(Cl)C=C3)=O)=C1C)NCCN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (24.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4100 mL | 12.0502 mL | 24.1005 mL | 60.2511 mL |
| 5 mM | 0.4820 mL | 2.4100 mL | 4.8201 mL | 12.0502 mL | |
| 10 mM | 0.2410 mL | 1.2050 mL | 2.4100 mL | 6.0251 mL | |
| 15 mM | 0.1607 mL | 0.8033 mL | 1.6067 mL | 4.0167 mL | |
| 20 mM | 0.1205 mL | 0.6025 mL | 1.2050 mL | 3.0126 mL |
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